GASTROPROTECTIVE EFFECTS OF ZINC AND VITAMIN E ON SOME BIOCHEMICAL AND HISTOLOGICAL CHANGES ON ETHANOL-INDUCED MUCOSAL DAMAGE IN WISTAR RATS

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dc.contributor.authorOLAJIDE, Oladunni
dc.date.accessioned2015-03-06T12:29:39Z
dc.date.available2015-03-06T12:29:39Z
dc.date.issued2014-06
dc.descriptionA THESIS SUBMITTED TO THE SCHOOL OF POSTGRADUATE STUDIES, AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE AWARD OF MASTERS DEGREE IN BIOCHEMISTRY. DEPARTMENT OF BIOCHEMISTRY, FACULTY OF SCIENCE AHMADU BELLO UNIVERSITY, ZARIA, NIGERIA JUNE, 2014en_US
dc.description.abstractAntiulcerogenic effects of zinc, vitamin E and their combination on ethanol-induced ulcerogenic rats were investigated using standard methods. The rats treated with the combination of zinc and vitamin E, followed by those treated with zinc alone and those treated with the standard drug, cimetidine had significantly (P < 0.05) higher antiulcerogenic properties as indicated by their preventive indices of 92.44 %, 89.92 %, and 73.11 % respectively compared to the rats treated with vitamin E alone (49.58 %). Antioxidant studies revealed that vitamin E (10.01 ± 0.54 μmol/g tissue), zinc (8.77 ± 0.55μmol/g tissue) and their combination (8.52 ± 0.87 μmol/g tissue) exerted higher protective effects against lipid peroxidation, which was significantly (P < 0.05) lower than the ulcerogenic rats that were not treated and which had a value of 11.30 ±0.15 μmol/g tissue. Superoxide dismutase (2.08 ± 0.10 U/g tissue) and glutathione peroxidase (43.17 ± 0.38 U/g tissue) activities increased significantly (P < 0.05) in the ulcerogenic groups treated with vitamin E, compared with the normal control group (1.63 ± 0.14 U/g tissue; 39.61 ± 3.18 U/g tissue). Catalase activity in the group treated with vitamin E (49.61 ± 1.73 U/g tissue) showed no significant (P > 0.05) difference compared with the normal control group (48.55 ± 2.76 U/g tissue) but was significantly (P < 0.05) different from the group treated with zinc (42.64 ± 2.73 U/g tissue). There was a significant (P < 0.05) increase in the packed cell volume (56.2 ± 3.01 %), haemoglobin concentration ((17.62 ± 0.76 g/dl) and red blood cell count (10.22 ± 0.71 x 106/μl) of the ulcerogenic rats without treatment compared to all the other treatment groups and the normal control group.The mean corpuscular volume of the treatment groups indicated a significant (P < 0.05) increase (Vitamin E - 61.63 ± 0.22 fl; Zinc alone - 60.97 ± 0.73 fl; and Zinc+ Vitamin E - 60.63 ± 1.53 fl.) as compared to the normal control (55.07 ± 0.64 fl) and ulcerogenic rats without treatment (57.20 ± 0.96 fl). The leucocyte count decreased significantly (P < 0.05) in the treatment (Zinc - 7.2 ± 0.79 x 103/μl; Vitamin E - 5.8 ± 1.2 x 103/μl) and normal control groups (6.1 ± 1.3 x 103/μl) as compared to the ulcerogenic rats without any treatment (17.7 ± 1.7 x 103/μl). The result of the study showed that zinc and/or vitamin E has antiulcerogenic properties and that zinc and vitamin E enhance the integrity of blood cells in ulcerogenic rats. The results showed that vitamin E and zinc supplements are of great value in the development of new anti-ulcerogenic agents once the appropriate dosage and ratio are utilized.en_US
dc.identifier.urihttps://kubanni.abu.edu.ng/handle/123456789/6122
dc.language.isoenen_US
dc.subjectGASTROPROTECTIVE,en_US
dc.subjectZINC,en_US
dc.subjectVITAMIN,en_US
dc.subjectBIOCHEMICAL,en_US
dc.subjectHISTOLOGICAL,en_US
dc.subjectETHANOL,en_US
dc.subjectMUCOSAL,en_US
dc.subjectDAMAGE,en_US
dc.subjectWISTAR RATSen_US
dc.titleGASTROPROTECTIVE EFFECTS OF ZINC AND VITAMIN E ON SOME BIOCHEMICAL AND HISTOLOGICAL CHANGES ON ETHANOL-INDUCED MUCOSAL DAMAGE IN WISTAR RATSen_US
dc.typeThesisen_US
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