STUDIES ON THE RESISTANCE OF HOST RED BLOOD CELLS TO TRYPANOSOMA VIVAX PHOSPHOLIPASES

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dc.contributor.authorOGBADOYI, EMMANUEL OLOFU
dc.date.accessioned2014-02-11T12:23:11Z
dc.date.available2014-02-11T12:23:11Z
dc.date.issued1988-10
dc.descriptionA thesis submitted to the Post Graduate School, Department of Biochmistry, Ahmadu Bello University, Zaria in partial fulfilment of the requirements for the award of the Master of Science Degree in Biochemistry.en_US
dc.description.abstractFive goats were experimentally infected with Trypanesoma vivax and the packed cell volume (PCV), haemoglobin (Hb) levels and serum free fatty acid (FFA) levels were monitored. A cyolical fluctuation was observed in the development of parasitemia during the twenty-six-day period of infection with the highest peaks on days five and twelve. There was a general gradual decrease in both the PCV and the Hb levels of all the infected animals, an indication of progressive anaemia. The anaemia became very severe by day twenty-six post infection as shown by the very low values of the PCV and Hb levels. One of the infected animals died of acut infection on day twenty-six post infection. Analysis for serum FFA showed a general increase in the FFA levels of all the infected animals throughout the period of infection. Investigation into the haemolytic activity of the isolated phospholipase A2 showed that the enzyme does not cause any significant haemolysis of host (bovine) erythrocytes in the absence of serum albumin. However, in the presence of 3.5% albumin, the enzyme caused up to 70% haemolysis. In the presence of 20mM EDTA, a potent inhibitor of phospholipase A2?, only 8.0% haemolysis was observed. The development of drugs for the treatment of anaemia in trypanosomiasis using inhibitors of phospholipases is therefore suggesteden_US
dc.identifier.urihttp://hdl.handle.net/123456789/1262
dc.language.isoenen_US
dc.subjectSTUDIESen_US
dc.subjectRESISTANCEen_US
dc.subjectHOSTen_US
dc.subjectREDen_US
dc.subjectBLOODen_US
dc.subjectCELLSen_US
dc.subjectTRYPANOSOMA VIVAXen_US
dc.subjectPHOSPHOLIPASESen_US
dc.titleSTUDIES ON THE RESISTANCE OF HOST RED BLOOD CELLS TO TRYPANOSOMA VIVAX PHOSPHOLIPASESen_US
dc.typeThesisen_US
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