SEROPREVALENCE OF CYTOMEGALOVIRUS INFECTION AMONG PREGNANT WOMEN IN KADUNA STATE, NIGERIA

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dc.contributor.authorYEROH, MICHAEL
dc.date.accessioned2014-02-06T10:10:08Z
dc.date.available2014-02-06T10:10:08Z
dc.date.issued2012-10
dc.descriptionA THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL, AHMADU BELLO UNIVERSITY, ZARIA NIGERIAen_US
dc.description.abstractHuman Cytomegalovirus is a major public health problem throughout the world. It is the leading cause of congenital infections leading to neurological disabilities in children that result to severe sequelae such as sensor neural hearing loss, neurodevelopment delay, or blindness. This study was conducted to determine the seroprevalence of human cytomegalovirus among pregnant women in Kaduna State, Nigeria. Three hundred and sixty three (363) blood samples were collected from 330 pregnant women attending antenatal clinics and (33) from non pregnant women attending the out patient department in three selected General hospitals in Kaduna State. The blood samples were examined for the presence of CMV IgG antibodies by ELISA and IFA methods. About 93.3% and 94.8% of pregnant women tested positive to CMV IgG antibodies by ELISA and IFA respectively while 93.9% and 100% of non pregnant women tested positive by both methods respectively. There was no statistically significant association between human Cytomegalovirus infection and pregnancy by both methods (2=0.018, df=2, p=0.894 ELISA and 2=1.784, df=2, p=0.182 IFA). Infection with Human Cytomegalovirus was strongly associated with the pregnant women by geographical zone (2=8.864, df,=2, p=0.012 by ELISA and 2=15.381, df=2, p=0.000 by IFA) and employment status (2=2.894, df=1, p=0.089 by ELISA which was weak and 2=5.624, df=1, p=0.018 by IFA). There was no significant association between HCMV infection and age, parity, gestation, education, number of marriages and previous transfusion by both ELISA and IFA. As a result of the high prevalence of CMV infection observed in this study, it is advisable that routine screening of CMV infection be implemented for all antenatal women in the State. The sensitivity and specificity of IFA in relation to ELISA in this study was 96.1% and 17.4% respectively. Kappa test showed a slight degree of agreement between ELISA and IFA results obtained in this study and Kappa was significant at p= 0.003.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/408
dc.language.isoenen_US
dc.subjectSEROPREVALENCEen_US
dc.subjectCYTOMEGALOVIRUSen_US
dc.subjectINFECTIONen_US
dc.subjectPREGNANTen_US
dc.subjectWOMENen_US
dc.subjectKADUNA STATEen_US
dc.subjectNIGERIAen_US
dc.titleSEROPREVALENCE OF CYTOMEGALOVIRUS INFECTION AMONG PREGNANT WOMEN IN KADUNA STATE, NIGERIAen_US
dc.typeThesisen_US
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