THE BIOCHEMICAL EFFECTS OF ACUTE AND SUB-CHRONIC ADMINISTRATION OF ASUNTOLR (COUMAPHOS) ON THE LIVER OF RATS

Simple item page
dc.contributor.authorTARFA, YERIMA PETER
dc.date.accessioned2014-02-14T09:40:49Z
dc.date.available2014-02-14T09:40:49Z
dc.date.issued1995-01
dc.descriptionA THESIS SUBMITTED TO THE POST GRADUATE SCHOOL AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILMENT OF THE REQUIREMENT FOR THE AWARD OF THE DEGREE OF MASTER OF SCIENCE IN BIOCHEMISTRY. DEPARTMENT OF BIOCHEMISTRY FACULTY OF SCIENCES AHMADU BELLO UNIVERSITY ZARIA - NIGERIA. JANUARY, 1995en_US
dc.description.abstractThe acute and sub-chronic toxicity of AsuntolR (Coumaphos) on the liver of rats were studied using biochemical methods. Seventy eight albino rats of both sexes aged between 1 - 2 months old, weighing between 78g to 108g constituted the study population. The rats were fed ad-libitum with local layer marsh bounded with wheat flour for both acute and sub-chronic studies for a period of 8 weeks. Pre-determined levels of coumaphos were added to the feeds for the sub-chronic study, while no coumaphos was added the feeds for acute study. Results of the acute toxicity test showed a moderate toxicity in rats (139.6mg/kg). For the sub-chronic studies, highest dose of 2 00mg/kg feed caused a significant (P < 0.05) increase in the levels of AST in the serum after the first four weeks of feeding trial, while it caused a significant (P < 0.05) decrease in ALT levels after the eight weeks. Lower doses of lOmg and lOOmg/kg feed showed no significant decrease in the levels of AST throughout the duration of the study. There was a significant decrease in the level of serum ALT with the lOOmg dose throughout the duration of the study. A significant (P < 0.05) decrease in the serum levels of ALP was observed with all three doses at one stage or the other during the study. No significant change was observed throughout the study in the serum total protein and albumin levels which indicates normal protein turnover in the animals.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/1509
dc.language.isoenen_US
dc.subjectBIOCHEMICAL,en_US
dc.subjectEFFECTS,en_US
dc.subjectACUTE,en_US
dc.subjectSUB-CHRONIC,en_US
dc.subjectADMINISTRATION,en_US
dc.subjectASUNTOLR,en_US
dc.subjectCOUMAPHOS,en_US
dc.subjectLIVER,en_US
dc.subjectRATS.en_US
dc.titleTHE BIOCHEMICAL EFFECTS OF ACUTE AND SUB-CHRONIC ADMINISTRATION OF ASUNTOLR (COUMAPHOS) ON THE LIVER OF RATSen_US
dc.typeThesisen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
THE BIOCHEMICAL EFFECTS OF ACUTE AND SUB CHRONIC ADMINISTRATION OF ASUNTOLR COUMAPHOS ON THE LIVER OF RATS.pdf
Size:
4.86 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.58 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
SCIENCE