THE BIOCHEMICAL EFFECTS OF ACUTE AND SUB-CHRONIC ADMINISTRATION OF ASUNTOLR (COUMAPHOS) ON THE LIVER OF RATS
THE BIOCHEMICAL EFFECTS OF ACUTE AND SUB-CHRONIC ADMINISTRATION OF ASUNTOLR (COUMAPHOS) ON THE LIVER OF RATS
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Date
1995-01
Authors
TARFA, YERIMA PETER
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Abstract
The acute and sub-chronic toxicity of AsuntolR (Coumaphos) on
the liver of rats were studied using biochemical methods. Seventy
eight albino rats of both sexes aged between 1 - 2 months old,
weighing between 78g to 108g constituted the study population.
The rats were fed ad-libitum with local layer marsh bounded
with wheat flour for both acute and sub-chronic studies for a
period of 8 weeks. Pre-determined levels of coumaphos were added to
the feeds for the sub-chronic study, while no coumaphos was added
the feeds for acute study.
Results of the acute toxicity test showed a moderate toxicity
in rats (139.6mg/kg). For the sub-chronic studies, highest dose of
2 00mg/kg feed caused a significant (P < 0.05) increase in the
levels of AST in the serum after the first four weeks of feeding
trial, while it caused a significant (P < 0.05) decrease in ALT
levels after the eight weeks. Lower doses of lOmg and lOOmg/kg feed
showed no significant decrease in the levels of AST throughout the
duration of the study. There was a significant decrease in the
level of serum ALT with the lOOmg dose throughout the duration of
the study. A significant (P < 0.05) decrease in the serum levels of
ALP was observed with all three doses at one stage or the other
during the study.
No significant change was observed throughout the study in the
serum total protein and albumin levels which indicates normal
protein turnover in the animals.
Description
A THESIS SUBMITTED TO THE POST GRADUATE SCHOOL
AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL
FULFILMENT OF THE REQUIREMENT FOR THE AWARD
OF THE DEGREE OF MASTER OF SCIENCE
IN BIOCHEMISTRY.
DEPARTMENT OF BIOCHEMISTRY
FACULTY OF SCIENCES
AHMADU BELLO UNIVERSITY
ZARIA - NIGERIA.
JANUARY, 1995
Keywords
BIOCHEMICAL,, EFFECTS,, ACUTE,, SUB-CHRONIC,, ADMINISTRATION,, ASUNTOLR,, COUMAPHOS,, LIVER,, RATS.