PHYTOCHEMICAL AND MEDICINAL PROPERTIES OF EXTRACTS OF THE LEAVES OF PEUCEDANUM WINKLERI H. WOLFF

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dc.contributor.authorMADUMELU, MARK
dc.date.accessioned2014-08-15T09:18:50Z
dc.date.available2014-08-15T09:18:50Z
dc.date.issued2014-03
dc.descriptionA THESIS SUBMITTED TO THE SCHOOL OF POSTGRADUATE STUDIES, AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILLMENT FOR THE AWARD OF A MASTER DEGREE IN ORGANIC CHEMISTRY DEPARTMENT OF CHEMISTRY, FACULTY OF SCIENCE AHMADU BELLO UNIVERSITY, ZARIA NIGERIA MARCH, 2014en_US
dc.description.abstractPhytochemical investigation of the leaves of Peucedanum winkleri. H. Wolff, revealed the presence of carbohydrates, free reducing sugar, cardiac glycoside, saponins, steroids, flavanoids, alkaloids, tannins and triterpenes. The extracts were screened for their antimicrobial activity against Staphylococcus aureus, Methicillin resistant Staphylococcus aureus, Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, Corynebacterium ulcerans, Klebsiella pneumoniae, Streptococcus pyogenes, Candida albicans, Candida tropicalis, Candida krusei and Proteus mirabilis. The result indicated that the extracts inhibited the growth of one or more test pathogens. The ethyl acetate extract showed a broad spectrum of antimicrobial activity.4-(4-Chlorophenyl)-3-cyclohexyl-1-methyl-6-(2-naphthoyl)-1,2,3,4-tetrahydro-1,2,4,5-Tetrazine was isolated from the ethyl acetate extract of the plant leaves by means of Vacuum liquid chromatography (VLC), Thin layer chromatography (TLC) and Preparative thin layer chromatography (PTLC) using a solvent mixture of 1:1 v/v petroleum-ether and ethyl acetate. The stucture was established mainly by MS, IR, 1H and 13C NMR including DEPT spectroscopy. Also the isolated compound was able to inhibit the growths of some of the microorganisms used for the studies. The result of the study justified the use of the plant against several infectious diseases.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/5234
dc.language.isoenen_US
dc.subjectPHYTOCHEMICAL,en_US
dc.subjectMEDICINAL,en_US
dc.subjectPROPERTIES,en_US
dc.subjectEXTRACTS,en_US
dc.subjectLEAVES,en_US
dc.subjectPEUCEDANUM WINKLERIen_US
dc.subjectH. WOLFF.en_US
dc.titlePHYTOCHEMICAL AND MEDICINAL PROPERTIES OF EXTRACTS OF THE LEAVES OF PEUCEDANUM WINKLERI H. WOLFFen_US
dc.typeThesisen_US
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