THE EFFECTS OF SOME LOCAL STARCHES ON THE PROPERTIES OF GRANULES AND TABLETS

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dc.contributor.authorKUNLE, OLOBAYO OLUFUNSHO
dc.date.accessioned2014-02-06T09:37:27Z
dc.date.available2014-02-06T09:37:27Z
dc.date.issued1988-06
dc.descriptionA THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL, AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE AWARD OF THE DEGREE OF MASTER OF SCIENCE IN PHARMACEUTICSen_US
dc.description.abstractStarches have been extracted from the fresh tubers of yam (Diascorea rotundata) and cassava (Mannihot utilissima) and cocoyam (Colocasia esculenta) rhizome. The starches extracted were subjected to the B.P. (1980) identification tests for starches which they all passed. The starch particle size, swelling power, moisture sorption capacity, moisture content, mucilage viscosity and the effect of temperature on the viscosity of the mucilages were determined. These were also determined for the official maize starch. The local starches and the official maize starch were used as binders and disintegrants in the preparation of granulations and tablets of sulphadimidine and promethazine. The comparative effects of all the starches on the properties and quality of granulations and tablets were determined. The properties of granulations studied were size distribution, moisture content flowability, bulk/tapped densities of tablets were investigated included hardness, friability, packing fraction, disintegration time and dissolution rates. Differences were observed in the properties of granules and tablets made with the different starches. These have been explained based on the fundamental properties of the starches used. (viii)en_US
dc.identifier.urihttp://hdl.handle.net/123456789/384
dc.language.isoenen_US
dc.subjectEFFECTSen_US
dc.subjectSOMEen_US
dc.subjectLOCALen_US
dc.subjectSTARCHESen_US
dc.subjectROPERTIESen_US
dc.subjectGRANULESen_US
dc.subjectTABLETSen_US
dc.titleTHE EFFECTS OF SOME LOCAL STARCHES ON THE PROPERTIES OF GRANULES AND TABLETSen_US
dc.typeThesisen_US
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