THE EFFECTS OF SOME LOCAL STARCHES ON THE PROPERTIES OF GRANULES AND TABLETS
THE EFFECTS OF SOME LOCAL STARCHES ON THE PROPERTIES OF GRANULES AND TABLETS
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Date
1988-06
Authors
KUNLE, OLOBAYO OLUFUNSHO
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Abstract
Starches have been extracted from the fresh tubers
of yam (Diascorea rotundata) and cassava (Mannihot
utilissima) and cocoyam (Colocasia esculenta) rhizome.
The starches extracted were subjected to the B.P.
(1980) identification tests for starches which they all
passed. The starch particle size, swelling power,
moisture sorption capacity, moisture content, mucilage
viscosity and the effect of temperature on the viscosity
of the mucilages were determined. These were also
determined for the official maize starch.
The local starches and the official maize starch
were used as binders and disintegrants in the preparation
of granulations and tablets of sulphadimidine and
promethazine. The comparative effects of all the
starches on the properties and quality of granulations
and tablets were determined. The properties of
granulations studied were size distribution, moisture
content flowability, bulk/tapped densities of tablets
were investigated included hardness, friability,
packing fraction, disintegration time and dissolution
rates.
Differences were observed in the properties of
granules and tablets made with the different starches.
These have been explained based on the fundamental
properties of the starches used.
(viii)
Description
A THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL, AHMADU
BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILMENT OF THE
REQUIREMENTS FOR THE AWARD OF THE DEGREE OF MASTER OF
SCIENCE IN PHARMACEUTICS
Keywords
EFFECTS, SOME, LOCAL, STARCHES, ROPERTIES, GRANULES, TABLETS