ANTIMICROBIAL AND WOUND HEALING POTENTIALS OF LEAF AND STEM EXTRACTS OF CATHARANTHUS ROSEUS, MITRACARPUS SCABER AND SENNA ALATA IN RATS

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dc.contributor.authorMALLUM, MIDAWA SABASTIAN
dc.date.accessioned2014-02-26T11:51:06Z
dc.date.available2014-02-26T11:51:06Z
dc.date.issued2011-03
dc.descriptionA THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL, AHMADU BELLO UNIVERSITY, ZARIA, IN PARTIAL FULFILLMENT OF THE REQUIREMENT FOR AWARD OF MASTER SCIENCE EDUCATIONAL BIOLOGY, DEPARTMENT OF BIOLOGICAL SCIENCES, AHMADU BELLO UNIVERSITY, ZARIA NIGERIA. 30th March, 2011en_US
dc.description.abstractThe leaves and stems of Catharanthus roseus (L), Mitracarpus scaber (L) and Senna alata (L) were screened for their antimicrobial and phytochemical properties. Ethanol was used as the solvent of extraction of the plant samples. The leaves and stems extracts of C. roseus, M. scaber and S. alata were investigated at 250 and 500mg for wound healing activities on excision model in laboratory Rats. The antimicrobial activities of the plant samples were tested against standard organisms, Staphylococcus aureus (ATCC 02101), Escherichia coli (ATTC 11775), Pseudosomonas aeruginosa (ATTC 10145) and the laboratory isolates of Candida albicans and Aspergillus niger. The plant samples were also screened for the bioactive constituents which includes Carbohydrates, Glycosides, Free anthraquinones, Combined anthracene, Cardiac glycosides, Steroids, Triterpenes, Flavonoids, Tannins, Alkaloids and Saponins. The Free anthraquinones were absent in all the plant samples tested. Glycosides were absent in the leaf and the Combined anthracene was absent in the stem extracts of Mitracarpus scaber. The stem extracts of Senna alata also revealed the absence of Flavonoids, Tannins and Alkaloids while the other phytoconstituents remain the same in all the plant samples. The activities of the extracts showed both bacteriostatic and fungistatic effects. The MICs and the MBC/MFC, ranges from 0.0625 – 0.5mg. The ethanolic extracts of all the plant samples did not exert toxic effects on the Mice used in the toxicity screening. The animals treated with the ethanolic extracts of the plants used in this study showed a significant wound healing response compared to those that received negative (placebo) treatment. The mean wound healing response of the extracts treated groups range from 16.01 – 20.88 days. While the positive was 14.60 days and the negative was 22.91 days. The wound healing properties of the plants may be associated with their antimicrobial activity and also the observed photochemical. The percentage wound healing contractions along with the antimicrobial activities support the use of the three plant samples in the topical management of wound healing. Thus the traditional claims of the uses of the plants in the treatment of wounds are therefore justified.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/2785
dc.language.isoenen_US
dc.subjectANTIMICROBIAL,en_US
dc.subjectWOUND HEALINGen_US
dc.subjectPOTENTIALS,en_US
dc.subjectLEAF AND STEM,en_US
dc.subjectEXTRACTS,en_US
dc.subjectCATHARANTHUS,en_US
dc.subjectROSEUS,en_US
dc.subjectMITRACARPUS,en_US
dc.subjectSCABER,en_US
dc.subjectSENNA,en_US
dc.subjectALATA,en_US
dc.subjectRATSen_US
dc.titleANTIMICROBIAL AND WOUND HEALING POTENTIALS OF LEAF AND STEM EXTRACTS OF CATHARANTHUS ROSEUS, MITRACARPUS SCABER AND SENNA ALATA IN RATSen_US
dc.typeThesisen_US
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