ANTI-DIABETIC EFFECT OF LEMONGRASS (CYMBOPOGON CITRATUS STAPF) TEA IN TYPE 2 DIABETIC RATS
ANTI-DIABETIC EFFECT OF LEMONGRASS (CYMBOPOGON CITRATUS STAPF) TEA IN TYPE 2 DIABETIC RATS
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Date
2021-03
Authors
ANCHAU, Husaina Garba
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Abstract
Lemongrass (Cymbopogon citratus Stapf) tea is commonly consumed as food and for the
traditional treatment of diabetes mellitus locally. This study was conducted to investigate the
effect of lemongrass tea (LGT) in type 2 diabetes mellitus (T2DM) rats model. Forty-two (42)
animals were randomly divided into 6 groups of seven animals each: Normal Control (NC),
Diabetic Control (DBC), Diabetic Lemongrass Tea Low (DLTL, was administered
0.25g/100ml/kg BW of the lemongrass tea), Diabetic treated with metformin (DMF 150mg/kg
BW), Diabetic Lemongrass Tea High (DLTH) and Normal Lemongrass Tea High (NLTH)
were administered 0.5g/100ml/kg BW of the lemongrass tea. T2DM was induced in rats by
feeding 10% fructose solution ad libitum for two weeks followed by intra-peritoneal (i.p)
injection of streptozotocin (STZ, 40mg/kg BW) in all animals except NC and NLTH groups.
The phytochemical analysis of lemongrass tea and cold water extract was compared using
standard methods. From the results, the hot LGT showed higher phytochemical constituents
compared to cold water extract, except for saponins. The LGT treatment at both dosages
significantly (p < 0.05) reduced blood glucose level and dyslipidemia compared to DBC
while NLTH was within the normal range. There were significant (p < 0.05) improvements in
oral glucose tolerance ability, weight gain, decreased food and fluid intakes. Similarly,
serum insulin concentration, pancreatic β-cell function and liver glycogen content were
significantly (p < 0.05) increased in DLTL, DLTH groups when compared to DBC group.
The results obtained in this study validate the traditional usage of LGT for management of
diabetes treatment and suggest that both lower and higher (0.25/100ml/kg and 0.5/100ml/kg)
doses of LGT are effective to reduce most of the diabetes associated complications in a T2D model of rats
Description
A DISSERTATION SUBMITTED TO THE SCHOOL OF POSTGRADUATE
STUDIES, AHMADU BELLO UNIVERSITY, ZARIA
IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF
MASTER OF SCIENCE DEGREE IN BIOCHEMISTRY
DEPARTMENT OF BIOCHEMISTRY,
FACULTY OF LIFE SCIENCES,
AHMADU BELLO UNIVERSITY,
ZARIA, KADUNA STATE, NIGERIA
Keywords
ANTI-DIABETIC EFFECT,, LEMONGRASS,, (CYMBOPOGON CITRATUS STAPF),, TEA,, TYPE 2 DIABETIC RATS.