ANTI-DIABETIC EFFECT OF LEMONGRASS (CYMBOPOGON CITRATUS STAPF) TEA IN TYPE 2 DIABETIC RATS

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dc.contributor.authorANCHAU, Husaina Garba
dc.date.accessioned2021-10-26T08:15:01Z
dc.date.available2021-10-26T08:15:01Z
dc.date.issued2021-03
dc.descriptionA DISSERTATION SUBMITTED TO THE SCHOOL OF POSTGRADUATE STUDIES, AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF MASTER OF SCIENCE DEGREE IN BIOCHEMISTRY DEPARTMENT OF BIOCHEMISTRY, FACULTY OF LIFE SCIENCES, AHMADU BELLO UNIVERSITY, ZARIA, KADUNA STATE, NIGERIAen_US
dc.description.abstractLemongrass (Cymbopogon citratus Stapf) tea is commonly consumed as food and for the traditional treatment of diabetes mellitus locally. This study was conducted to investigate the effect of lemongrass tea (LGT) in type 2 diabetes mellitus (T2DM) rats model. Forty-two (42) animals were randomly divided into 6 groups of seven animals each: Normal Control (NC), Diabetic Control (DBC), Diabetic Lemongrass Tea Low (DLTL, was administered 0.25g/100ml/kg BW of the lemongrass tea), Diabetic treated with metformin (DMF 150mg/kg BW), Diabetic Lemongrass Tea High (DLTH) and Normal Lemongrass Tea High (NLTH) were administered 0.5g/100ml/kg BW of the lemongrass tea. T2DM was induced in rats by feeding 10% fructose solution ad libitum for two weeks followed by intra-peritoneal (i.p) injection of streptozotocin (STZ, 40mg/kg BW) in all animals except NC and NLTH groups. The phytochemical analysis of lemongrass tea and cold water extract was compared using standard methods. From the results, the hot LGT showed higher phytochemical constituents compared to cold water extract, except for saponins. The LGT treatment at both dosages significantly (p < 0.05) reduced blood glucose level and dyslipidemia compared to DBC while NLTH was within the normal range. There were significant (p < 0.05) improvements in oral glucose tolerance ability, weight gain, decreased food and fluid intakes. Similarly, serum insulin concentration, pancreatic β-cell function and liver glycogen content were significantly (p < 0.05) increased in DLTL, DLTH groups when compared to DBC group. The results obtained in this study validate the traditional usage of LGT for management of diabetes treatment and suggest that both lower and higher (0.25/100ml/kg and 0.5/100ml/kg) doses of LGT are effective to reduce most of the diabetes associated complications in a T2D model of ratsen_US
dc.identifier.urihttp://hdl.handle.net/123456789/12655
dc.language.isoenen_US
dc.subjectANTI-DIABETIC EFFECT,en_US
dc.subjectLEMONGRASS,en_US
dc.subject(CYMBOPOGON CITRATUS STAPF),en_US
dc.subjectTEA,en_US
dc.subjectTYPE 2 DIABETIC RATS.en_US
dc.titleANTI-DIABETIC EFFECT OF LEMONGRASS (CYMBOPOGON CITRATUS STAPF) TEA IN TYPE 2 DIABETIC RATSen_US
dc.typeThesisen_US
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