FFECTS OF EXPERIMENTAL Trypanosoma evansi INFECTION ON PREGNANCY AND SOME PREGNANCY ASSOCIATED SERUM FACTORS INYANKASA EWES
FFECTS OF EXPERIMENTAL Trypanosoma evansi INFECTION ON PREGNANCY AND SOME PREGNANCY ASSOCIATED SERUM FACTORS INYANKASA EWES
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Date
2015-08
Authors
ADEYEYE, Adewale Ayodeji
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Abstract
Twenty pregnantYankasa ewes which were oestrus synchronized and mated naturally were assigned into 3 groups according to their weights, to determine the effect of Trypanosomaevansiinfection on pregnancy and some pregnancy associated serum factors. Groups A and B comprising7 ewes each were infected with approximately 1.0 x106 of T. evansi per ewe through venipunctureat the second and third trimesters of pregnancy, respectively. Group C comprising 6 ewes served as uninfected control. Parasitaemia was detected between days 11 and 25 post-infection (pi) and between days 13 and 22 pi in groups A and B, respectively and fluctuated thereafter, while ewes in group C remained aparasitaemic throughout the study. There was slight pyrexia in the infected groups (A and B) but absent in group C. The mean body weight changes, glucose concentration and packed cell volume (PCV) of ewes in group A were not significantly(p>0.05) different from those in group C throughout the study. There was also no significant (p>0.05) difference in mean glucose concentration between group B and C. However, in group B, the mean body weight was significantly(p<0.05) lower compared to group C at week 2 and from week 4 pi till the end of the study; the PCV also significantly(p<0.05) decreased but at weeks 4 and 6 pi only. Leukopenia was observed in group A at week 1 pi, followed by leukocytosis at week 4 pi and then leukopenia at week 7 pi. Ewes in group B also showed leukopenia but at week 3 pi and thiscoincided with peak parasitaemia. The mean plasma protein (PPr) of ewes in group A was significantly(p<0.05)increasedcompared to those of group C at weeks 7and 11 pi, thereafter till the end of the study. On the contrary, the PPr of ewes in group B decreased significantly(p<0.05) compared to group C at weeks 2 and 6 pi.The mean progesterone (P4) and pregnancy associated glycoprotein (PAG) levels of ewes
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A DISSERTATION SUBMITTED TO THE SCHOOL OF POSTGRADUATE STUDIES, AHMADU BELLO UNIVERSITY, ZARIA
IN PARTIAL FULFILLMENT OF THEREQUIREMENTS FOR THE AWARD OF A DOCTOR OF PHILOSOPHY IN THERIOGENOLOGY
DEPARTMENT OF THERIOGENOLOGY AND PRODUCTION
AHMADU BELLO UNIVERSITY, ZARIA
Keywords
FFECTS,, EXPERIMENTAL Trypanosoma evansi INFECTION,, PREGNANCY,, PREGNANCY ASSOCIATED SERUM,, FACTORS INYANKASA EWES,