CHEMICAL ANALYSES OF THE ROOT BARKS OF DETARIUM MICROCARPUM GUILL&PERR. AND SCLEROCARYA BIRREA (A.RICH) HOCHST. FOR ANTIFEEDANT AND ANTIMICROBIAL PROPERTIES

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dc.contributor.authorHASSAN, MUNIRAT MODUPE
dc.date.accessioned2014-03-05T07:51:56Z
dc.date.available2014-03-05T07:51:56Z
dc.date.issued2004-05
dc.descriptionA Thesis Submitted to the Postgraduate School, Ahmadu Bello University, Zaria. In Partial Fulfillment of the Requirements for the Award of Master of Science Degree in Organic Chemistry Department of Chemistry Faculty of Science Ahmadu Bello University, Zaria, Nigeria.en_US
dc.description.abstractThe extracts of the root barks of Detarium microcarpum Guill&Perr and Sclerocarya birrea (A.Rich) Hochst. have found traditional use in Nigeria and other African countries for treatment of dysentery, skin diseases and as antifeedant against stored product pests. These claims have been verified through antifeedant, cytotoxicty and microbial tests. Phytochemical analyses carried out on the extracts of both plants (using solvents of varying polarities) showed the presence of reducing sugars, alkaloids, saponin glycosides, sterols, resins and balsams, flavonoids and tannins. All the extracts (except for the petroleum spirit extract) from the two plants were active against Bacillus subtilis, Escherichia coli, Cornybacterium pyogenes, Staphyloccocus aureus and Salmonella typhi. The methanol and ethyl acetate extracts from both plants were active in the shrimp lethality bioassay (Cytotoxicity Test). The methanol extracts of the plants had good antifeedant activity. Purification of the methanol fraction of the S. birrea extract was carried out to determine the components of the plant. The petroleum spirit extract tested positive for aldehyde and this was oxidized to the acid derivative in order to facilitate its isolation and purification. Infra Red and Nuclear Magnetic Resonance spectroscopic analyses were carried out to determine the possible structures of compounds obtained.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/3223
dc.language.isoenen_US
dc.subjectCHEMICAL,en_US
dc.subjectANALYSES,en_US
dc.subjectROOT,en_US
dc.subjectBARKS,en_US
dc.subjectDETARIUM,en_US
dc.subjectMICROCARPUM,en_US
dc.subjectGUILL&PERR,en_US
dc.subjectSCLEROCARYA,en_US
dc.subjectBIRREA,en_US
dc.subjectHOCHST,en_US
dc.subjectANTIFEEDANT,en_US
dc.subjectANTIMICROBIAL,en_US
dc.subjectPROPERTIESen_US
dc.titleCHEMICAL ANALYSES OF THE ROOT BARKS OF DETARIUM MICROCARPUM GUILL&PERR. AND SCLEROCARYA BIRREA (A.RICH) HOCHST. FOR ANTIFEEDANT AND ANTIMICROBIAL PROPERTIESen_US
dc.typeThesisen_US
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