CHEMICAL ANALYSES OF THE ROOT BARKS OF DETARIUM MICROCARPUM GUILL&PERR. AND SCLEROCARYA BIRREA (A.RICH) HOCHST. FOR ANTIFEEDANT AND ANTIMICROBIAL PROPERTIES
CHEMICAL ANALYSES OF THE ROOT BARKS OF DETARIUM MICROCARPUM GUILL&PERR. AND SCLEROCARYA BIRREA (A.RICH) HOCHST. FOR ANTIFEEDANT AND ANTIMICROBIAL PROPERTIES
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Date
2004-05
Authors
HASSAN, MUNIRAT MODUPE
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Abstract
The extracts of the root barks of Detarium microcarpum Guill&Perr and
Sclerocarya birrea (A.Rich) Hochst. have found traditional use in Nigeria and
other African countries for treatment of dysentery, skin diseases and as antifeedant
against stored product pests.
These claims have been verified through antifeedant, cytotoxicty and
microbial tests. Phytochemical analyses carried out on the extracts of both plants
(using solvents of varying polarities) showed the presence of reducing sugars,
alkaloids, saponin glycosides, sterols, resins and balsams, flavonoids and tannins.
All the extracts (except for the petroleum spirit extract) from the two plants were
active against Bacillus subtilis, Escherichia coli, Cornybacterium pyogenes,
Staphyloccocus aureus and Salmonella typhi.
The methanol and ethyl acetate extracts from both plants were active in the
shrimp lethality bioassay (Cytotoxicity Test). The methanol extracts of the plants
had good antifeedant activity. Purification of the methanol fraction of the S. birrea
extract was carried out to determine the components of the plant. The petroleum
spirit extract tested positive for aldehyde and this was oxidized to the acid
derivative in order to facilitate its isolation and purification. Infra Red and Nuclear
Magnetic Resonance spectroscopic analyses were carried out to determine the
possible structures of compounds obtained.
Description
A Thesis Submitted to the Postgraduate School, Ahmadu Bello
University, Zaria. In Partial Fulfillment of the Requirements for
the Award of Master of Science Degree in Organic Chemistry
Department of Chemistry
Faculty of Science
Ahmadu Bello University,
Zaria, Nigeria.
Keywords
CHEMICAL,, ANALYSES,, ROOT,, BARKS,, DETARIUM,, MICROCARPUM,, GUILL&PERR,, SCLEROCARYA,, BIRREA,, HOCHST,, ANTIFEEDANT,, ANTIMICROBIAL,, PROPERTIES