EVALUATION OFDIGITARIA IBURUA (FAMILY POACEAE) STARCH AS A BINDER AND DISINTEGRANT IN A MACRO-DOSE TABLET FORMULATION
EVALUATION OFDIGITARIA IBURUA (FAMILY POACEAE) STARCH AS A BINDER AND DISINTEGRANT IN A MACRO-DOSE TABLET FORMULATION
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Date
2009-06
Authors
GAMBO, Aishatu
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Abstract
The study aims at formulating Paracetamol tablets using Digitaria iburua
(DI) starch as binder and disintegrant. Digitaria iburua starch was extracted
from Digitaria iburua grains using wet milling and sieving method and
thereafter purified. Pregelatinised Digitaria iburua starch (PGS DI) was also
prepared. Paracetamol granules were produced by wet granulation method
using these two starches as binders and disintegrants and the properties of
the granules were compared with gelatin as binder and Maize starch as
disintegrant. Properties of the granules and the resulting tablets were
determined thereafter compressed into tablets on a single station tablet press.
The percentage yield of the starch (DI) extracted was 62.20% w/w while that
of (PGS DI) was 73.18% w/w. Digitaria iburua starch when compared
with maize starch BP. as tablet binder showed similarity in the values of
their moisture content, swelling power, Hausner ratio, tapped and bulk
densities. However, there was superiority displayed in some properties such
as flow rate, angle of repose and true density. Increasing the concentration of
Digitaria iburua starch as tablet binder and disintegrant resulted in an
increase in tablet thickness, a decrease in friability and an increase in
disintegration time.
Compaction studies showed that DI starch and PGS when used as binder and
disintegrant produced granules that compact by initial fragmentation
followed by plastic deformation.
Description
A THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL
AHMADU BELLO UNIVERSITY IN PARTIAL
FULFILlMENT OF THE REQUIREMENTS FOR THE
AWARD OF MASTER OF SCIENCE IN PHARMACEUTICS
DEPARTMENT OF PHARMACEUTICS AND
PHARMACEUTICAL MICROBIOLOGY,
FACULTY OF MEDICINE,
AHMADU BELLO UNIVERSITY,
ZARIA, NIGERIA
Keywords
EVALUATION,, OFDIGITARIA IBURUA,, STARCH,, BINDER,, DISINTEGRANT,, MACRO-DOSE TABLET FORMULATION..