PHARMACOLOGICAL EVALUATION OF THE EXTRACT FROM Tephrosia bracteolata LEAVES IN LABORATORY ANIMALS

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dc.contributor.authorONAOLAPO, MARY ADEROJU OLALONPE
dc.date.accessioned2014-02-07T09:38:14Z
dc.date.available2014-02-07T09:38:14Z
dc.date.issued2000-08
dc.descriptionA THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL, AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE (BIOCHEMISTRY).en_US
dc.description.abstractTephrosia bracteolata is a legume widely spread in the Northern and Southern states of Nigeria and commonly known as "Kimi or Shege" in Hausa and "Roro" in Yoruba. The plant is employed as a fodder for animals and for various medicinal purposes, especially as a pain killer. Hence, the present pharmacological studies were carried out on the plant leaves. The crude extract of the leaves of Tephrosia bracteolata, which was found to be nontoxic (LD50 > 5,000), induced a dose-dependent contractile response in guinea pig ileum. It possesses no significant antimicrobial activity, but contains a potent analgesic principle. The most effective dose for the analgesic activity was 400 mg/kg. The crude extract was also found to possess a potent antipyretic activity at a dose of 600 mg/kg, which compared very favourably with that of the standard drug, aspirin. The anti-inflammatory studies revealed that the crude extract inhibited inflammation. At a dose of 800 mg/kg body weight, the inhibition of a carrageenan induced oedema two (2) hours post-induction was 57 percent compared to the 40 percent inhibition by the standard anti-inflammatory drug, indomethacin. The plant extract did not potentiate barbiturate sleeping time, thus; the plant extract contains principles ossessing a potent non-narcotic analgesic, with both antipyretic and anti-inflammatory, properties.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/592
dc.language.isoenen_US
dc.subjectPHARMACOLOGICALen_US
dc.subjectEVALUATIONen_US
dc.subjectEXTRACTen_US
dc.subjectTephrosiaen_US
dc.subjectbracteolataen_US
dc.subjectLEAVESen_US
dc.subjectLABORATORYen_US
dc.subjectANIMALSen_US
dc.titlePHARMACOLOGICAL EVALUATION OF THE EXTRACT FROM Tephrosia bracteolata LEAVES IN LABORATORY ANIMALSen_US
dc.typeThesisen_US
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