PHARMACOLOGICAL EVALUATION OF THE EXTRACT FROM Tephrosia bracteolata LEAVES IN LABORATORY ANIMALS
PHARMACOLOGICAL EVALUATION OF THE EXTRACT FROM Tephrosia bracteolata LEAVES IN LABORATORY ANIMALS
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Date
2000-08
Authors
ONAOLAPO, MARY ADEROJU OLALONPE
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Abstract
Tephrosia bracteolata is a legume widely spread in the Northern and Southern states of Nigeria and commonly known as "Kimi or Shege" in Hausa and "Roro" in Yoruba. The plant is employed as a fodder for animals and for various medicinal purposes, especially as a pain killer. Hence, the present pharmacological studies were carried out on the plant leaves. The crude
extract of the leaves of Tephrosia bracteolata, which was found to be nontoxic
(LD50 > 5,000), induced a dose-dependent contractile response in guinea pig ileum. It possesses no significant antimicrobial activity, but contains a potent analgesic principle. The most effective dose for the
analgesic activity was 400 mg/kg. The crude extract was also found to possess a potent antipyretic activity at a dose of 600 mg/kg, which compared very favourably with that of the standard drug, aspirin. The anti-inflammatory studies revealed that the crude extract inhibited inflammation. At a dose of 800 mg/kg body weight, the inhibition of a carrageenan induced oedema two (2) hours post-induction was 57 percent compared to the 40 percent inhibition
by the standard anti-inflammatory drug, indomethacin. The plant extract did not potentiate barbiturate sleeping time, thus; the plant extract contains principles ossessing a potent non-narcotic analgesic, with both antipyretic and anti-inflammatory, properties.
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A THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL,
AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE (BIOCHEMISTRY).
Keywords
PHARMACOLOGICAL, EVALUATION, EXTRACT, Tephrosia, bracteolata, LEAVES, LABORATORY, ANIMALS