DETERMINATION OF TOLL LIKE RECEPTOR-2 LEVEL AND OTHER NONSPECIFIC IMMUNE PARAMETERS ASSOCIATED WITH PLASMODIUM INFECTION IN PATIENTS ATTENDING SELECTED HOSPITALS IN ZARIA, NIGERIA

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dc.contributor.authorISA, BALA USMAN
dc.date.accessioned2026-02-02T11:35:24Z
dc.date.available2026-02-02T11:35:24Z
dc.date.issued2023-06
dc.descriptionA DISSERTATION SUBMITTED TO THE SCHOOL OF POSTGRADUATE STUDIES, AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF MASTERS DEGREE IN MICROBIOLOGY DEPARTMENT OF MICROBIOLOGY FACULTY OF LIFE SCIENCES AHMADU BELLO UNIVERSITY, ZARIA NIGERIA
dc.description.abstractInvading malaria parasites are recognized by TLR2 and engulfed by the innate immune cells. Malaria is a blood disease caused by the bite of female mosquito and accounts for more than one million deaths every year. The aim of this study was to determine TLR2 level and other nonspecific innate immune parameters in patients with Plasmodium infection inselected hospitals in Zaria, Kaduna State, Nigeria. A hundred and eighty (180) bloodsamples were collected and analyzed.Malaria parasite antigen was detected using Rapid Diagnostic Test (Biosensor and Encode) while malaria parasite density,differential blood count and total white blood count (TWBC) were determined microscopically.The level of TLR2 concentration was determined using ELISA (Fine test).The overall prevalence of Plasmodium infection recorded was 17.7%. The mean and standard deviation of parasite density obtained from this study were 1878.94±289 parasite/μl. The mean concentrations of TLR2 recorded in malaria parasite positive and negative patients were 0.662ng/ml and 0.566ng/ml respectively. There was an inverse correlation of-0.149 between parasitemia and TLR2 which implies that an increase in parasitemia leads to a decrease in TLR2 level and vice versa. In this study, only the difference between PCV and TWBC in malaria parasite positive and negative patients were statistically significant (p<0.05). Age group of ≤10, herbal treatment for malaria and non-use of treated bed nets were factors associated with Plasmodium infection(p<0.05). This research has shown that TLR2 and other non-specific innate immune cells could help in suppressing the level of Plasmodium infection in the body.
dc.identifier.urihttps://kubanni.abu.edu.ng/123456789/13183
dc.language.isoen
dc.titleDETERMINATION OF TOLL LIKE RECEPTOR-2 LEVEL AND OTHER NONSPECIFIC IMMUNE PARAMETERS ASSOCIATED WITH PLASMODIUM INFECTION IN PATIENTS ATTENDING SELECTED HOSPITALS IN ZARIA, NIGERIA
dc.typeThesis
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