DETERMINATION OF TOLL LIKE RECEPTOR-2 LEVEL AND OTHER NONSPECIFIC IMMUNE PARAMETERS ASSOCIATED WITH PLASMODIUM INFECTION IN PATIENTS ATTENDING SELECTED HOSPITALS IN ZARIA, NIGERIA
DETERMINATION OF TOLL LIKE RECEPTOR-2 LEVEL AND OTHER NONSPECIFIC IMMUNE PARAMETERS ASSOCIATED WITH PLASMODIUM INFECTION IN PATIENTS ATTENDING SELECTED HOSPITALS IN ZARIA, NIGERIA
No Thumbnail Available
Date
2023-06
Authors
ISA, BALA USMAN
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Invading malaria parasites are recognized by TLR2 and engulfed by the innate immune cells.
Malaria is a blood disease caused by the bite of female mosquito and accounts for more than one
million deaths every year. The aim of this study was to determine TLR2 level and other nonspecific
innate immune parameters in patients with Plasmodium infection inselected hospitals in
Zaria, Kaduna State, Nigeria. A hundred and eighty (180) bloodsamples were collected and
analyzed.Malaria parasite antigen was detected using Rapid Diagnostic Test (Biosensor and
Encode) while malaria parasite density,differential blood count and total white blood count
(TWBC) were determined microscopically.The level of TLR2 concentration was determined
using ELISA (Fine test).The overall prevalence of Plasmodium infection recorded was 17.7%.
The mean and standard deviation of parasite density obtained from this study were 1878.94±289
parasite/μl. The mean concentrations of TLR2 recorded in malaria parasite positive and negative
patients were 0.662ng/ml and 0.566ng/ml respectively. There was an inverse correlation of-0.149
between parasitemia and TLR2 which implies that an increase in parasitemia leads to a decrease
in TLR2 level and vice versa. In this study, only the difference between PCV and TWBC in
malaria parasite positive and negative patients were statistically significant (p<0.05). Age group
of ≤10, herbal treatment for malaria and non-use of treated bed nets were factors associated with
Plasmodium infection(p<0.05). This research has shown that TLR2 and other non-specific innate
immune cells could help in suppressing the level of Plasmodium infection in the body.
Description
A DISSERTATION SUBMITTED TO THE SCHOOL OF POSTGRADUATE
STUDIES,
AHMADU BELLO UNIVERSITY, ZARIA
IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD
OF
MASTERS DEGREE IN MICROBIOLOGY
DEPARTMENT OF MICROBIOLOGY
FACULTY OF LIFE SCIENCES
AHMADU BELLO UNIVERSITY,
ZARIA NIGERIA