SERUM VITAMIN C AND SOME HAEMATOLOGICAL INDICES IN HEALTHY SUBJECTS AND IN PATIENTS WITH SICKLE CELL ANAEMIA
SERUM VITAMIN C AND SOME HAEMATOLOGICAL INDICES IN HEALTHY SUBJECTS AND IN PATIENTS WITH SICKLE CELL ANAEMIA
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Date
1996-07
Authors
OLADIMEJI, RAJI WASIU
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Abstract
Scrum vitamin C, haemoglobin, packed cell volume and mean corpuscular
haemoglobin concentration were measured in healthy subjects and in sickle cell anaemia
(SCA) patients attending the Sickle Cell Clinic at Ahmadu Bello University Teaching
Hospital, Zaria. The relationships between sex/age and these parameters were also
examined. Sixty seven SCA patients homozygous for hacmoglobin-S and forty-four normal
subjects homozygous for hacmoglobin-A were used in this study. There was no significant
difference in the mean serum vitamin C levels between SCA patients and normal subjects
(0.603 ± 0.07 Vs 0.602 ± 0.05). This suggests that SCA patients studied were vitamin C
sufficient. On the basis of sex, no significant difference (P>0.05) was observed in the
serum vitamin C levels between male and female SCA patients, however, the male normal
subjects had a significantly lower (P<0.05) vitamin C levels than the female normal
subjects. The mean serum vitamin C levels in normal male subjects was 0.479 ± 0.06 and
the male SCA patients had 0.608 ± 0.09. There was no significant difference (P>0.05)
between these observed serum vitamin C levels. Similarly, there was no significant
difference (P >0.05) in serum vitamin C levels between female SCA patients and normal
female subjects. Serum vitamin C decreased with increasing age among normal subjects and
among SCA patients. However, no significant difference was found in serum vitamin C
levels between SCA patients and normal subjects for the age groups (18-22 and 23-27)
considered in this study. Mean haemoglobin (Hb) levels were significantly lower in SCA
patients than the normal subjects and this difference persisted irrespective of age or sex.
Packed cell volume (PCV) followed a similar trend as Hb in both SCA patients and normal
subjects. The mean corpuscular haemoglobin concentration (MCHC) was independent of age
and sex; and no significant difference was found between SCA patient and normal subjects.
Correlation between serum vitamin C and Hb levels was negative in both sexes irrespective
of state of health, (SCA patients and normal subjects having values of r = -0.285, P<0.019
and r=-0.387, P<0.008, respectively).
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Description
A THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL,
AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL
FULFILMENT OF THE REQUIREMENTS FOR THE AWARD OF
THE DEGREE OF MASTER OF SCIENCE IN BIOCHEMISTRY.
Keywords
SERUM, VITAMIN, SOME, HAEMATOLOGICAL, INDICES, HEALTHY, SUBJECTS, PATIENTS, SICKLE CELL, ANAEMIA