SERUM VITAMIN C AND SOME HAEMATOLOGICAL INDICES IN HEALTHY SUBJECTS AND IN PATIENTS WITH SICKLE CELL ANAEMIA

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dc.contributor.authorOLADIMEJI, RAJI WASIU
dc.date.accessioned2014-02-10T10:42:02Z
dc.date.available2014-02-10T10:42:02Z
dc.date.issued1996-07
dc.descriptionA THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL, AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE AWARD OF THE DEGREE OF MASTER OF SCIENCE IN BIOCHEMISTRY.en_US
dc.description.abstractScrum vitamin C, haemoglobin, packed cell volume and mean corpuscular haemoglobin concentration were measured in healthy subjects and in sickle cell anaemia (SCA) patients attending the Sickle Cell Clinic at Ahmadu Bello University Teaching Hospital, Zaria. The relationships between sex/age and these parameters were also examined. Sixty seven SCA patients homozygous for hacmoglobin-S and forty-four normal subjects homozygous for hacmoglobin-A were used in this study. There was no significant difference in the mean serum vitamin C levels between SCA patients and normal subjects (0.603 ± 0.07 Vs 0.602 ± 0.05). This suggests that SCA patients studied were vitamin C sufficient. On the basis of sex, no significant difference (P>0.05) was observed in the serum vitamin C levels between male and female SCA patients, however, the male normal subjects had a significantly lower (P<0.05) vitamin C levels than the female normal subjects. The mean serum vitamin C levels in normal male subjects was 0.479 ± 0.06 and the male SCA patients had 0.608 ± 0.09. There was no significant difference (P>0.05) between these observed serum vitamin C levels. Similarly, there was no significant difference (P >0.05) in serum vitamin C levels between female SCA patients and normal female subjects. Serum vitamin C decreased with increasing age among normal subjects and among SCA patients. However, no significant difference was found in serum vitamin C levels between SCA patients and normal subjects for the age groups (18-22 and 23-27) considered in this study. Mean haemoglobin (Hb) levels were significantly lower in SCA patients than the normal subjects and this difference persisted irrespective of age or sex. Packed cell volume (PCV) followed a similar trend as Hb in both SCA patients and normal subjects. The mean corpuscular haemoglobin concentration (MCHC) was independent of age and sex; and no significant difference was found between SCA patient and normal subjects. Correlation between serum vitamin C and Hb levels was negative in both sexes irrespective of state of health, (SCA patients and normal subjects having values of r = -0.285, P<0.019 and r=-0.387, P<0.008, respectively). ven_US
dc.identifier.urihttp://hdl.handle.net/123456789/871
dc.language.isoenen_US
dc.subjectSERUMen_US
dc.subjectVITAMINen_US
dc.subjectSOMEen_US
dc.subjectHAEMATOLOGICALen_US
dc.subjectINDICESen_US
dc.subjectHEALTHYen_US
dc.subjectSUBJECTSen_US
dc.subjectPATIENTSen_US
dc.subjectSICKLE CELLen_US
dc.subjectANAEMIAen_US
dc.titleSERUM VITAMIN C AND SOME HAEMATOLOGICAL INDICES IN HEALTHY SUBJECTS AND IN PATIENTS WITH SICKLE CELL ANAEMIAen_US
dc.typeThesisen_US
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