INDUCTION OF MAMMARY TUMOUR IN ALBINO RATS BY 7,12-DIMETHYLBENZ(a) ANTHRACENE SUSPENDED IN TWO VEGETABLE OILS

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dc.contributor.authorJAKES, OMAGE JEBBA
dc.date.accessioned2014-02-10T13:01:03Z
dc.date.available2014-02-10T13:01:03Z
dc.date.issued1990-12
dc.descriptionA THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL, AHMADU BBLLO UNIVERSITY, ZARIA, IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE AVARD OF THE DEGREE OF MASTER OF SCIENCE Department of biochemistry Faculty of Science Ahmadu Bello University Zariaen_US
dc.description.abstractThe susceptibility of female albino rats to mammary tumour induction by 7, 12-di-methylbenz(a) anthracene (DMBA) dissolved in two types of oils was investigated. Female albino rats (aged 54 days) were intubated with BKBA (65mg/>;g body weight) dissolved in either sesame seed oil (Group A) or soyabean oil (Group B). The Influence of DMBA on male rata was alao investigated by intubating mole albino rate with DMBA in soyabean oil (Group C) or sesame seed oil (Group D). The animals were fed laboratory animal chow (Pfizer-Ladokun feed), weighed weekly and the females were palpated for mammary tumour development starting 3 weeks post intubation. At 42 weeks, all surviving animals were killed by decapitation,. At necropsy, blood and tissue samples were taken for biochemical analysis, haemntological studies and histopnthological examination. In the females, biochemical profile shows significantly (P < 0.05) higher levels of total serum protein and total serum cholesterol in the soyabean oil group than the sesame seed oil group. The liver weight was also significantly (P < 0.05) higher in the soyabean oil group than the sesame seed oil group. to significant (P > 0.05) differences were observed between the two groups in growth rate, body weight gain, haematocrit, haemoglobin and lymphocyte counts. In the males, biochemical profile shows significantly (P < 0.05) higher levels of total serum protein and total serum cholesterol in the soyabean oil group than the sesame seed oil group. There was significant (P < 0.05) difference in body weight gain and growth pattern between the two treatment groups. There was significantly (P < 0.05> higher scrotal sac and liver weights in the sesame seed oil group than the soyabean oil group. There was significant <P < 0.05) difference in the haematocrit, and haemoglobin levels while no differences (P > 0.05) were observed in tne lymphocyte counts of both treatment groups. While soyabean oil may be substituted for sesame seed oil as DMBA solvent, the oil and the use of albino rats as a model for mammary tumourigenes and scrotal sac development requires further investigation. -en_US
dc.identifier.urihttp://hdl.handle.net/123456789/981
dc.language.isoenen_US
dc.subjectINDUCTION,en_US
dc.subjectMAMMARY TUMOUR,en_US
dc.subjectALBINO RATS,en_US
dc.subject7,12-DIMETHYLBENZ,en_US
dc.subjectANTHRACENE SUSPENDED,en_US
dc.subjectVEGETABLE OILSen_US
dc.titleINDUCTION OF MAMMARY TUMOUR IN ALBINO RATS BY 7,12-DIMETHYLBENZ(a) ANTHRACENE SUSPENDED IN TWO VEGETABLE OILSen_US
dc.typeThesisen_US
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