HUMAN RESPIRATORY SYNCYTIAL VIRUS INFECTION AMONG CHILDREN 1-5 YEARS IN ZARIA, KADUNA STATE, NIGERIA
HUMAN RESPIRATORY SYNCYTIAL VIRUS INFECTION AMONG CHILDREN 1-5 YEARS IN ZARIA, KADUNA STATE, NIGERIA
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Date
2009-03
Authors
ALIYU, AISHATU MOHAMMED
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Abstract
Serological survey was carried out among children in Zaria to determine the level of
Respiratory syncytial virus IgG antibodies. Blood samples of children aged 12 –60 months
were collected in three out patient clinics of Ahmadu Bello University Teaching Hospital
Zaria. Respiratory syncytial virus IgG antibody level was measured using commercial ELISA
kit obtained from DEMEDITEC DIAGNOSTIC GmbH Germany. Three hundred and eighty
four blood samples, were collected how ever 379 were analyzed due to lyses of some. Of the
379 blood samples analyzed, 353 (93.1%) were seropositive for Respiratory Syncytial Virus.
There was female predominance, with 178 (94.2%) being positive compared to males
175(92.1%) but the difference was not statistically significant (P value >0.05). However,
statistical association was observed between age and seropositivity (P value<0.05). The
seroprevalence was highest (98.7%) in age group 49-60 months and lowest in age group 0-12
months (78.6%). There was no association between the presence of cough, catarrh and/or
running nose with seropositivity (P value >0.05). The result also shows no association with
the presence of sickle cell disease and parental smoking with seropositivity (p value >0.05).
This study has revealed that children ages 1-5 years have very high prevalence of RSV
infection in Zaria, and therefore, highlighting the need for the younger age group to be
targeted for prevention programme against RSV infection
Description
A THESIS SUBMITTED TO THE
POSTGRADUATE SCHOOL,
AHMADU BELLO UNIVERSITY, ZARIA
NIGERIA
IN PARTIAL FULFILLMENT FOR THE AWARD OF
MASTERS OF SCIENCE IN
MICROBIOLOGY
DEPARTMENT OF MICROBIOLOGY
AHMADU BELLO UNIVERSITY, ZARIA
NIGERIA
MARCH 2009
Keywords
HUMAN, RESPIRATORY, SYNCYTIAL, VIRUS, INFECTION, AMONG, CHILDREN 1-5 YEARS, ZARIA,, KADUNA, NIGERIA