EFFECTS OF JAPANESE QUAIL (Coturnix japonica) EGG SUPPLEMENTATION ON POLOXAMER 407-INDUCED HYPERLIPIDEMIC WISTAR RATS

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dc.contributor.authorADENIYI, OLUWAMAYOWA TOLULOPE
dc.date.accessioned2015-08-19T10:06:51Z
dc.date.available2015-08-19T10:06:51Z
dc.date.issued2014-10
dc.descriptionEFFECTS OF JAPANESE QUAIL (Coturnix japonica) EGG SUPPLEMENTATION ON POLOXAMER 407-INDUCED HYPERLIPIDAEMIC WISTAR RATS BY Oluwamayowa Tolulope ADENIYI B. Sc (ABU, 2006) (M.Sc/Scien/03490/2009-2010) A THESIS SUBMITTED TO THE SCHOOL OF POSTGRADUATE STUDIES, AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILLMENT OF THE REQUIREMENT FOR THE AWARD OF THE DEGREE OF MASTER OF SCIENCE IN BIOCHEMISTRY DEPARTMENT OF BIOCHEMISTRY, FACULTY OF SCIENCE AHMADU BELLO UNIVERSITY ZARIA, KADUNA STATE NIGERIA OCTOBER 2014en_US
dc.description.abstractThe effects of Japanese quail egg on lipid profile and haematological parameters, antioxidant effect, liver and kidney functions were investigated in poloxamer 407-induced (P407) hyperlipidaemic wistar rats. Sixty rats were grouped into ten. Each group consisting of six rats each of mixed sexes for the purpose of preventive and curative studies. Groups 1, 2, 3 and 4, served as normal control group, two positive control groups, and hyperlipidaemic control group respectively. In the preventive study, groups 5, 6 and 7 were administered Atorvastatin, 0.64ml/kg and 10ml/kg of quail egg respectively for 19 days before the induction of hyperlipidaemia with poloxamer 407 and sacrificed 48 hr later. In the curative study, groups 8, 9 and 10 were induced with hyperlipidaemia before administering Atorvastatin, 0.64ml/kg and 10ml/kg of quail egg respectively and sacrificed 48 hr after. The parameters were determined using standard Methods. In the preventive study, total cholesterol, triacylglycerol, HDL-cholesterol and LDL-cholesterol, total protein, total and conjugated bilirubin, albumin, urea and creatinine level show no significant (p>0.05) difference between P407-induced egg treated groups and the P407- induced hyperlipidaemic control group. The atherogenic risk predictor indices (HDL-c/TC, LDL-c/HDL-c), the serum levels of alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) show no significant (p>0.05) difference in the P407-induced egg treated group compared to the P407-induced hyperlipidaemic control groups. The activity of catalase (CAT) and superoxide dismutase (SOD) was significant (p<0.05) higher in the P407-induced egg treated group compared to the P407-induced hyperlipidaemic control group. The level of malonyl dialdehyde (MDA) was significantly (p<0.05) lower in the P407-induced egg treated groups compared to the hyperlipidaemic viii control group. In the curative study, total cholesterol, triacylglycerol and HDL-cholesterol, total protein, total and conjugated bilirubin, albumin, urea, creatinine, ALP, AST levels and atherogenic risk predictor indices (HDL-c/TC, LDL-c/HDL-c) were not significantly (p>0.05) different between the P407-induced egg treated groups and the P407-induced hyperlipidaemic control group. However, ALT and MDA levels were significantly (p<0.05) lower in the P407-induced egg treated groups compared to the P407-induced hyperlipidaemic control group. The activities of SOD and CAT were significantly (p<0.05) higher in the P407-induced egg treated groups compared to the P407-induced hyperlipidaemic control group. Therefore, the quail egg possesses properties that prevent lipid peroxidation and may have potential benefits in the management of oxidative stress associated with the hyperlipidaemia.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/6773
dc.language.isoenen_US
dc.subjectEFFECTSen_US
dc.subjectJAPANESE QUAILen_US
dc.subjectEGG SUPPLEMENTATIONen_US
dc.subjectPOLOXAMERen_US
dc.subject407-INDUCED HYPERLIPIDAEMICen_US
dc.subjectWISTAR RATSen_US
dc.titleEFFECTS OF JAPANESE QUAIL (Coturnix japonica) EGG SUPPLEMENTATION ON POLOXAMER 407-INDUCED HYPERLIPIDEMIC WISTAR RATSen_US
dc.typeThesisen_US
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