EFFECTS OF JAPANESE QUAIL (Coturnix japonica) EGG SUPPLEMENTATION ON POLOXAMER 407-INDUCED HYPERLIPIDEMIC WISTAR RATS
EFFECTS OF JAPANESE QUAIL (Coturnix japonica) EGG SUPPLEMENTATION ON POLOXAMER 407-INDUCED HYPERLIPIDEMIC WISTAR RATS
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Date
2014-10
Authors
ADENIYI, OLUWAMAYOWA TOLULOPE
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Abstract
The effects of Japanese quail egg on lipid profile and haematological parameters,
antioxidant effect, liver and kidney functions were investigated in poloxamer 407-induced
(P407) hyperlipidaemic wistar rats. Sixty rats were grouped into ten. Each group consisting
of six rats each of mixed sexes for the purpose of preventive and curative studies. Groups 1,
2, 3 and 4, served as normal control group, two positive control groups, and
hyperlipidaemic control group respectively. In the preventive study, groups 5, 6 and 7 were
administered Atorvastatin, 0.64ml/kg and 10ml/kg of quail egg respectively for 19 days
before the induction of hyperlipidaemia with poloxamer 407 and sacrificed 48 hr later. In
the curative study, groups 8, 9 and 10 were induced with hyperlipidaemia before
administering Atorvastatin, 0.64ml/kg and 10ml/kg of quail egg respectively and sacrificed
48 hr after. The parameters were determined using standard Methods. In the preventive
study, total cholesterol, triacylglycerol, HDL-cholesterol and LDL-cholesterol, total
protein, total and conjugated bilirubin, albumin, urea and creatinine level show no
significant (p>0.05) difference between P407-induced egg treated groups and the P407-
induced hyperlipidaemic control group. The atherogenic risk predictor indices (HDL-c/TC,
LDL-c/HDL-c), the serum levels of alkaline phosphatase (ALP), alanine aminotransferase
(ALT) and aspartate aminotransferase (AST) show no significant (p>0.05) difference in the
P407-induced egg treated group compared to the P407-induced hyperlipidaemic control
groups. The activity of catalase (CAT) and superoxide dismutase (SOD) was significant
(p<0.05) higher in the P407-induced egg treated group compared to the P407-induced
hyperlipidaemic control group. The level of malonyl dialdehyde (MDA) was significantly
(p<0.05) lower in the P407-induced egg treated groups compared to the hyperlipidaemic
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control group. In the curative study, total cholesterol, triacylglycerol and HDL-cholesterol,
total protein, total and conjugated bilirubin, albumin, urea, creatinine, ALP, AST levels and
atherogenic risk predictor indices (HDL-c/TC, LDL-c/HDL-c) were not significantly
(p>0.05) different between the P407-induced egg treated groups and the P407-induced
hyperlipidaemic control group. However, ALT and MDA levels were significantly (p<0.05)
lower in the P407-induced egg treated groups compared to the P407-induced
hyperlipidaemic control group. The activities of SOD and CAT were significantly (p<0.05)
higher in the P407-induced egg treated groups compared to the P407-induced
hyperlipidaemic control group. Therefore, the quail egg possesses properties that prevent
lipid peroxidation and may have potential benefits in the management of oxidative stress
associated with the hyperlipidaemia.
Description
EFFECTS OF JAPANESE QUAIL (Coturnix japonica) EGG SUPPLEMENTATION ON
POLOXAMER 407-INDUCED HYPERLIPIDAEMIC WISTAR RATS
BY
Oluwamayowa Tolulope ADENIYI
B. Sc (ABU, 2006)
(M.Sc/Scien/03490/2009-2010)
A THESIS SUBMITTED TO THE SCHOOL OF POSTGRADUATE STUDIES,
AHMADU BELLO UNIVERSITY, ZARIA
IN PARTIAL FULFILLMENT OF THE REQUIREMENT FOR THE AWARD OF THE
DEGREE OF MASTER OF SCIENCE IN BIOCHEMISTRY
DEPARTMENT OF BIOCHEMISTRY, FACULTY OF SCIENCE
AHMADU BELLO UNIVERSITY ZARIA,
KADUNA STATE NIGERIA
OCTOBER 2014
Keywords
EFFECTS, JAPANESE QUAIL, EGG SUPPLEMENTATION, POLOXAMER, 407-INDUCED HYPERLIPIDAEMIC, WISTAR RATS