Preprint and Postprint Journal Articles

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Browsing Preprint and Postprint Journal Articles by Subject "2D NMR,"

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    Flavonoids with antimicrobial activity from the stem bark of Commiphora pedunculata (Kotschy 8t Peyr.) Engl.
    (2014-08-13) Tajuddeen, Nasir; M. S. Sallau,; Musa, Aliyu Muhammad; Habila, Dama James; Yahaya, Sani Muhammad
    The first reported investigation into the phytochemical constituents of Commiphora pedunculata led to the isolation of two flavonoids: kaempferol and dihydrokaempferol from the ethyl acetate-soluble fraction of the methanol extract of the stem bark of the plant. The structures of these compounds were characterised by comparing their spectral data including ID and 2D NMR with those reported in the literature. The two compounds were active against 6 out of 10 tested microorganisms including two resistant strains [methiciline-resistant Staphylococcus aureus and vancomycin- resistant entrococci (VRE)], Candida albicans and Escherichia coli. The zones of inhibition ranged between 24 and 30 mm for both compounds against the microorganisms. The MIC value was as low as 6.25 |xg/mL against VRE and Staphylococcus aureus. This is the first report of the isolation of these compounds from the plant.
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    A novel antimicrobial flavonoid from the stem bark of Commiphora pedunculata (Kotschy 8t Peyr.) Engl.
    (2015-05-15) Tajuddeen, Nasir; M. S. Sallau; Aliyu,M. Musa;Sani, M. Yahaya; Jame, D. Habila; Abdullahi, Musa Ismail
    A new flavonoid, 2-(3,5-dihydroxy-4-methoxy-phenyl)-3,5-dihydroxy-8,8-dimethyl- 2,3-dihydro-8H-pyrano[3,2]chromen-4-one, together with previously reported epica- techin was isolated from the ethyl acetate soluble fraction of the methanol extract of the stem bark of Commiphora pedunculata. The structures of these compounds were elucidated based on extensive analysis of their spectral data, including 1 and 2D NMR. The compounds were active against 9 out of 12 tested microorganisms including a resistant strain; vancomycin-resistant entrococci (VRE), Escherichia coli. Staphylo-coccus aureus and Candida albicans. The zones of inhibition ranged between 22 and 34 mm against the microorganisms. The minimum inhibitory concentration was as low as 6.25 µxg/mL against Shigella dysentriae. Bacillus cereus and S. aureus while the minimum bactericidal concentration was as low as 50 µxg/mL against Pseudomonas aeruginosa, VRE and C. albicans. This is the first report of the isolation of the compound.