A novel antimicrobial flavonoid from the stem bark of Commiphora pedunculata (Kotschy 8t Peyr.) Engl.
A novel antimicrobial flavonoid from the stem bark of Commiphora pedunculata (Kotschy 8t Peyr.) Engl.
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Date
2015-05-15
Authors
Tajuddeen, Nasir; M. S. Sallau; Aliyu,M. Musa;Sani, M. Yahaya; Jame, D. Habila; Abdullahi, Musa Ismail
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Abstract
A new flavonoid, 2-(3,5-dihydroxy-4-methoxy-phenyl)-3,5-dihydroxy-8,8-dimethyl-
2,3-dihydro-8H-pyrano[3,2]chromen-4-one, together with previously reported epica-
techin was isolated from the ethyl acetate soluble fraction of the methanol extract of the
stem bark of Commiphora pedunculata. The structures of these compounds were
elucidated based on extensive analysis of their spectral data, including 1 and 2D NMR.
The compounds were active against 9 out of 12 tested microorganisms including a
resistant strain; vancomycin-resistant entrococci (VRE), Escherichia coli. Staphylo-coccus aureus and Candida albicans. The zones of inhibition ranged between 22 and
34 mm against the microorganisms. The minimum inhibitory concentration was as low
as 6.25 µxg/mL against Shigella dysentriae. Bacillus cereus and S. aureus while the
minimum bactericidal concentration was as low as 50 µxg/mL against Pseudomonas
aeruginosa, VRE and C. albicans. This is the first report of the isolation of the
compound.
Description
Department of Chemistry, Ahmadu Bello University Zaria, Zaria 810282, Nigeria
Keywords
novel,, antimicrobial, flavonoid; VRE,, stem bark,, Commiphora pedunculata,, (Kotschy 8t Peyr.) Engl., 2D NMR,