Preprint and Postprint Journal Articles

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Browsing Preprint and Postprint Journal Articles by Subject "(Kotschy 8t Peyr.) Engl."

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    A novel antimicrobial flavonoid from the stem bark of Commiphora pedunculata (Kotschy 8t Peyr.) Engl.
    (2015-05-15) Tajuddeen, Nasir; M. S. Sallau; Aliyu,M. Musa;Sani, M. Yahaya; Jame, D. Habila; Abdullahi, Musa Ismail
    A new flavonoid, 2-(3,5-dihydroxy-4-methoxy-phenyl)-3,5-dihydroxy-8,8-dimethyl- 2,3-dihydro-8H-pyrano[3,2]chromen-4-one, together with previously reported epica- techin was isolated from the ethyl acetate soluble fraction of the methanol extract of the stem bark of Commiphora pedunculata. The structures of these compounds were elucidated based on extensive analysis of their spectral data, including 1 and 2D NMR. The compounds were active against 9 out of 12 tested microorganisms including a resistant strain; vancomycin-resistant entrococci (VRE), Escherichia coli. Staphylo-coccus aureus and Candida albicans. The zones of inhibition ranged between 22 and 34 mm against the microorganisms. The minimum inhibitory concentration was as low as 6.25 µxg/mL against Shigella dysentriae. Bacillus cereus and S. aureus while the minimum bactericidal concentration was as low as 50 µxg/mL against Pseudomonas aeruginosa, VRE and C. albicans. This is the first report of the isolation of the compound.