Preprint Journal Articles

Permanent URI for this collection

Now showing 1 - 1 of 1

SYNERGISTIC ACTIVITY OF METHANOLIC EXTRACT OF ADENIUM OBESUM (APOCYNACEAE) STEM-BARK AND OXYTETRACYCLINE AGAINST SOME CLINICAL BACTERIAL ISOLATES
(2011) Tijjani, A.; M. S. Sallau,; Sunusi, I.
Adenium obesum plant (stem-bark) was collected, identified, air-dried, ground and extracted using hot-continuous extraction method. Standard phytochemical tests and antimicrobial tests using Kirby and Bauer techniques were adopted for the phytochemical screening and antimicrobial tests of the plant stem-bark methanolic extract respectively. The MIC of methanolic extract in combination with oxytetracycline using 8 different clinical bacterial isolates, both Gram positive and Gram negative, was found to be around (62.5 pg/mi to 1250 pg/mi).In all, 87.5% showed synergistic activity against 8 different bacterial isolates, both gram positive and gram negative species. The highest synergistic activity was attained against Streptococcus pyogenes .Phytochemical examination of the extract revealed the presence of alkaloids, steroids, saponins, glycosides, anthraquinones, tannins and fiavonoids. This result indicated strong antibacterial activity of the methanolic extract in combination with oxytetracycline against the pathogenic bacterial isolates.