THE EFFECT OF SOLVENT COMPOSITION ON THE KINETICS OF DEACYLATION OF LECITHIN
THE EFFECT OF SOLVENT COMPOSITION ON THE KINETICS OF DEACYLATION OF LECITHIN
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Date
1985-02
Authors
ABALAKA, IDUH
JOHAH
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Abstract
A back titration technique has been used to follow up
the effect of change in the composition of the propan-1-ol/
water solvent on the kinetics of the deacylation of egg yolk
lecithin under second order conditions in alkaline media.
The lecithin was employed at a concentration of
1.5 x 10-2 molar and the alkali concentration was double that
of the lipid. The reaction was investigated in concentrations
of propan-1-ol ranging from 10 % v/v to 97 % v/v in water.
The work involved the withdrawal of aliquots of 1 cm3
from the reaction solvent which was maintained at a temperature
of 30O C under nitrogen reflux and magnetic stiringr
Withdrawn aliquots were titrated to phenolphthalein end point
using 3 x 10-3 molar hydrochloric acid and a 10 cm3 burette.
readable to 0.02 cm3. From the titre values obtained estimations
of the rate constants for the deacylation process in the
various compositions of the propan-1-ol in v/ater solvents
employed were obtained.
Association of lecithin in the various solvent systems
was examined spoctrophotometrically between 255 and 295 nm
using a Pye Unicam SP 30 digital, spectrophotometer using
phenolplrthaleln as a probe. The lecithin existed as monomers
in 83.33 % v/v propan-1-ol in water while various molecular
regates were formed in the other solvent systems.
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ABSTRACT
Description
A thesis submitted to the Postgraduate School
Ahmadu Bello University, in partial fulfillment of the
requirements for the degree of;
Master of Science in Pharmaceutics
Keywords
EFFECT, SOLVENT, COMPOSITION, KINETICS, DEACYLATION, LECITHIN