MODULATORY ROLE OF RESVERATROL-INDUCED DIETARY RESTRICTION AND ENVIRONMENTAL ENRICHMENT ON NEUROBEHAVIOURAL OUTCOME IN YOUNG HEALTHY MICE

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dc.contributor.authorMUHAMMAD, Mustapha Sheh
dc.date.accessioned2014-02-11T11:42:45Z
dc.date.available2014-02-11T11:42:45Z
dc.date.issued2013-04
dc.descriptionA THESIS SUBMITTED TO THE SCHOOL OF POSTGRADUATE STUDIES, AHMADU BELLO UNIVERSITY, ZARIA, NIGERIA IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE AWARD OF MASTER OF SCIENCE DEGREE IN HUMAN PHYSIOLOGY DEPARTMENT OF HUMAN PHYSIOLOGY AHMADU BELLO UNIVERSITY, ZARIA, NIGERIAen_US
dc.description.abstractDietary Restriction (DR) otherwise known as Caloric Restriction (CR) has been generally defined as consumption of nutritious diet that is 30% to 40% less in calories compared to ad libitum diet while Environmental Enrichment (EE) is defined as a sustained and progressive increase in cognitive and sensorimotor stimuli with aggregated voluntary physical activity and complex social interactions. The aim of this experiment was to investigate the modulatory role of Resveratrol induced CR and EE on neurobehavioural responses in young healthy mice. Twenty five mice of both sexes were divided into five groups of 5 animals each: group I served as the control and received carboxymethylcellulose (CMC) 50 mg per kg/day orally, group II animals were maintained on every other day feeding, group III animals received Resveratrol 50 mg/kg, suspended in 10 g/L of (CMC) orally per kg/day. Group IV animals received CMC and kept in an Enriched Environment while group V animals received Resveratrol 50 mg/kg and kept in an Enriched Environment. The treatment lasted for the period of four weeks. On day 26, 27 and 28 of the study period, the animals were subjected to neurobehavioural evaluation of motor coordination, motor strength, learning and memory. Brain and plasma samples were evaluated for lipid profile, lipid peroxidation and antioxidant enzymes. The results showed significant increase (P < 0.05) in the transfer latency (acquisition) in the every other day feeding group (69.20 ± 9.03 seconds) compared to the control group (36.80 ± 5.58 seconds). A significant increase (P <0.05) was observed in the concentration of low density lipoprotein (LDL) in every other day feeding group (1.72 ± 0.12 mg/dl) and environmental enrichment treatment group (1.73 ± 0.16 mg/dl) when compared to the control group (1.11 ± 0.07 mg/dl). The results obtained also showed significant decrease < 0.05) in MDA concentration in the Resveratrol treatment group kept in EE (1.50 ± 0.05 IU/L) compared to the control (1.84 ± 0.09 IU/L) and GPx activity in the Resveratrol treatment group kept in EE (41.00 ± 2.02 IU/L) compared to the control (59.00 ± 2.85 IU/L). In conclusion, the results obtained demonstrated that Resveratrol induced CR and EE have no effects on neurobehavioural responses coupled with some significant alterations in lipid profile, lipid peroxidation and antioxidant enzymes in young healthy mice over a period of four weeks.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/1226
dc.language.isoenen_US
dc.subjectMODULATORYen_US
dc.subjectROLEen_US
dc.subjectRESVERATROLen_US
dc.subjectINDUCEDen_US
dc.subjectDIETARYen_US
dc.subjectRESTRICTIONen_US
dc.subjectENVIRONMENTALen_US
dc.subjectENRICHMENTen_US
dc.subjectNEUROBEHAVIOURALen_US
dc.subjectOUTCOMEen_US
dc.subjectYOUNGen_US
dc.subjectHEALTHYen_US
dc.subjectMICEen_US
dc.titleMODULATORY ROLE OF RESVERATROL-INDUCED DIETARY RESTRICTION AND ENVIRONMENTAL ENRICHMENT ON NEUROBEHAVIOURAL OUTCOME IN YOUNG HEALTHY MICEen_US
dc.typeThesisen_US
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