THE INFLUENCE OF SOME FACTORS ON THE TECHNOLOGY AND QUALITY OF PARACETAMOL TABLETS
THE INFLUENCE OF SOME FACTORS ON THE TECHNOLOGY AND QUALITY OF PARACETAMOL TABLETS
| dc.contributor.author | AMOS, BODUNRIN BANGUDU | |
| dc.date.accessioned | 2014-02-04T13:34:42Z | |
| dc.date.available | 2014-02-04T13:34:42Z | |
| dc.date.issued | 1979 | |
| dc.description | A THESIS presented to Ahmadu Bello University in partial fulfillment for the degree of Master of Science Department of Pharmaceutics Faculty of Pharmaceutical Sciences Ahmadu Bello University ZARIA 1979 | en_US |
| dc.description.abstract | The various categories of pharmaceutical materials necessary for the fabrication of tablets (functional components), their specific role and mechanisms of action have been reviewed. The physics of tablet compression, the quality standards of tablets and the extent to which they can be interpreted an extrapolated to predict drug performance have been discussed. Paracetamol has been shown to compress poorly into tablets due to lamination and capping and the pharmaceutical factors/processes which modify the severity of this problem have been investigated. An investigation of the effect of binder type and concentration was conducted. The results show that fairly high concentrations of binder solutions are necessary to obtain satisfactory Paracetamol tablets. Gelatin solution and Polyvinyl i done (PVP) solution when used at concentration of 5 - 6%-w/w and 10%w/w respectively have been found to impart enough cohesive strength to paracetamol to produce firm tablets. It has been shown that using the wet granulation technique, paracetamol crystals do not offer any significant (iv) advantages over paracetamol powder in reducing tendency towards capping of paracetamol tablets. However, the crystals have been found to form better tablets than the powder employing the direct compression method. The incorporation of Tween 80 a non-ionic surfactant has been shown to exert no apparent influence on the consolidation of paracetamol and therefore irrelevant with respect to paracetamol tablet formulation. The particle size of granules undergoing consolidation have been shown to modify the compression characteristics of paracetamol. The results of the investigation show that paracetamol forms satisfactory tablets when the size of granules falls within the range 250 um - 1000 um An investigation of the effect of moisture content on quality of tablet was undertaken. It has been shown that the moisture content of granules plays a significant role in controlling the capping of paracetamol tablets and that to obtain satisfactory paracetamol tablets, the moisture content values should be within the range of 3 - 6%w/w. The effects of shapes of punches, compression pressure were investigated in a qualitative manner. The results indicated that these factors modify the compression behavior of paracetamol. The specific factors to be considered and steps to be taken consistent with the production of pharmaceutic-ally acceptable paracetamol tablets are outlined for large scale potential exploitation. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/225 | |
| dc.language.iso | en | en_US |
| dc.subject | INFLUENCE, | en_US |
| dc.subject | FACTORS, | en_US |
| dc.subject | TECHNOLOGY, | en_US |
| dc.subject | QUALITY, | en_US |
| dc.subject | PARACETAMOL. | en_US |
| dc.title | THE INFLUENCE OF SOME FACTORS ON THE TECHNOLOGY AND QUALITY OF PARACETAMOL TABLETS | en_US |
| dc.type | Thesis | en_US |