THE INFLUENCE OF SOME FACTORS ON THE TECHNOLOGY AND QUALITY OF PARACETAMOL TABLETS
THE INFLUENCE OF SOME FACTORS ON THE TECHNOLOGY AND QUALITY OF PARACETAMOL TABLETS
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Date
1979
Authors
AMOS, BODUNRIN BANGUDU
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Abstract
The various categories of pharmaceutical materials
necessary for the fabrication of tablets (functional
components), their specific role and mechanisms of action
have been reviewed.
The physics of tablet compression, the quality standards
of tablets and the extent to which they can be interpreted an
extrapolated to predict drug performance have been discussed.
Paracetamol has been shown to compress poorly into
tablets due to lamination and capping and the pharmaceutical
factors/processes which modify the severity of this problem
have been investigated.
An investigation of the effect of binder type and concentration
was conducted. The results show that fairly high
concentrations of binder solutions are necessary to obtain
satisfactory Paracetamol tablets. Gelatin solution and
Polyvinyl i done (PVP) solution when used at concentration
of 5 - 6%-w/w and 10%w/w respectively have been found to
impart enough cohesive strength to paracetamol to produce firm
tablets.
It has been shown that using the wet granulation technique,
paracetamol crystals do not offer any significant
(iv)
advantages over paracetamol powder in reducing tendency
towards capping of paracetamol tablets. However, the crystals
have been found to form better tablets than the powder
employing the direct compression method.
The incorporation of Tween 80 a non-ionic surfactant has
been shown to exert no apparent influence on the consolidation
of paracetamol and therefore irrelevant with respect to paracetamol
tablet formulation.
The particle size of granules undergoing consolidation
have been shown to modify the compression characteristics of
paracetamol. The results of the investigation show that
paracetamol forms satisfactory tablets when the size of
granules falls within the range 250 um - 1000 um
An investigation of the effect of moisture content on
quality of tablet was undertaken. It has been shown that the
moisture content of granules plays a significant role in
controlling the capping of paracetamol tablets and that to
obtain satisfactory paracetamol tablets, the moisture content
values should be within the range of 3 - 6%w/w.
The effects of shapes of punches, compression pressure
were investigated in a qualitative manner. The results indicated
that these factors modify the compression behavior
of paracetamol.
The specific factors to be considered and steps to be
taken consistent with the production of pharmaceutic-ally
acceptable paracetamol tablets are outlined for large scale
potential exploitation.
Description
A THESIS
presented to
Ahmadu Bello University in partial
fulfillment for the degree of
Master of Science
Department of Pharmaceutics
Faculty of Pharmaceutical Sciences
Ahmadu Bello University
ZARIA
1979
Keywords
INFLUENCE,, FACTORS,, TECHNOLOGY,, QUALITY,, PARACETAMOL.