COMPARISON OF ANTIBODY RESPONSE TO SINGLE SITE AND MULTIPLE SITES INJECTION USING ANTIRABIES VACCINE IN DOGS

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dc.contributor.authorOSINUBI, MODUPE OLUBUSOLA VIVIAN
dc.date.accessioned2014-11-04T08:53:53Z
dc.date.available2014-11-04T08:53:53Z
dc.date.issued1998-08
dc.descriptionA THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILLMENT FOR THE AWARD OF THE DEGREE OF MASTER OF SCIENCE (VETERINARY MEDICINE). DEPARTMENT OF VETERINARY SURGERY AND MEDICINE AHMADU BELLO UNIVERSITY ZARIA - NIGERIA. August, 1998en_US
dc.description.abstractA total of eighteen (18) dogs were immunized with the live attenuated low egg passage Flury strain rabies vaccine and killed Flury strain rabies vaccine using one, two and three inoculation sites for the recommended dose of each vaccine (in divided doses). Pre-immunization sera were collected from all the dogs while post-immunization sera were collected on days 3, 7, 10, 14 and 28 from all the dogs and analysed for viral neutralization antibody using mouse neutralization test (MNT). The two-site dose regimen of the killed vaccine induced measurable antibodies in all the subjects from day 3 post vaccination. This regimen proved to be superior to the single site standard dose regimen, which did not induce measurable antibodies until 7 days post vaccination. The antibody titres for single regimen were less than those of the two site regimen throughout the period of observation. The same condition was also observed when the live attenuated vaccine was used. The levels of neutralizing antibody production achieved with triplesite regimen were four times higher than those of the two-site regimen, irrespective of the type of vaccine used. All the dogs given the triple site regimen had measurable amount of antibody by day 28 post vaccination. A higher production of antibody was observed when live attenuated antirabies vaccine was used as indicated by an earlier protection than when the killed antirabies vaccine was used.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/5502
dc.language.isoenen_US
dc.subjectCOMPARISON,en_US
dc.subjectANTIBODY,en_US
dc.subjectMULTIPLE SITESen_US
dc.subjectANTIRABIES,en_US
dc.subjectVACCINE IN DOGSen_US
dc.titleCOMPARISON OF ANTIBODY RESPONSE TO SINGLE SITE AND MULTIPLE SITES INJECTION USING ANTIRABIES VACCINE IN DOGSen_US
dc.typeThesisen_US
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