COMPARISON OF ANTIBODY RESPONSE TO SINGLE SITE AND MULTIPLE SITES INJECTION USING ANTIRABIES VACCINE IN DOGS
COMPARISON OF ANTIBODY RESPONSE TO SINGLE SITE AND MULTIPLE SITES INJECTION USING ANTIRABIES VACCINE IN DOGS
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Date
1998-08
Authors
OSINUBI, MODUPE OLUBUSOLA VIVIAN
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Abstract
A total of eighteen (18) dogs were immunized with the live attenuated
low egg passage Flury strain rabies vaccine and killed Flury strain rabies
vaccine using one, two and three inoculation sites for the recommended dose
of each vaccine (in divided doses). Pre-immunization sera were collected
from all the dogs while post-immunization sera were collected on days 3, 7,
10, 14 and 28 from all the dogs and analysed for viral neutralization
antibody using mouse neutralization test (MNT).
The two-site dose regimen of the killed vaccine induced measurable
antibodies in all the subjects from day 3 post vaccination. This regimen
proved to be superior to the single site standard dose regimen, which did
not induce measurable antibodies until 7 days post vaccination. The
antibody titres for single regimen were less than those of the two site
regimen throughout the period of observation. The same condition was also
observed when the live attenuated vaccine was used.
The levels of neutralizing antibody production achieved with triplesite
regimen were four times higher than those of the two-site regimen,
irrespective of the type of vaccine used. All the dogs given the triple
site regimen had measurable amount of antibody by day 28 post vaccination.
A higher production of antibody was observed when live attenuated antirabies
vaccine was used as indicated by an earlier protection than when the killed
antirabies vaccine was used.
Description
A THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL
AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILLMENT
FOR THE AWARD OF THE DEGREE OF MASTER OF SCIENCE (VETERINARY MEDICINE).
DEPARTMENT OF VETERINARY SURGERY AND MEDICINE
AHMADU BELLO UNIVERSITY
ZARIA - NIGERIA.
August, 1998
Keywords
COMPARISON,, ANTIBODY,, MULTIPLE SITES, ANTIRABIES,, VACCINE IN DOGS