TOXICOLOGICAL INTERACTION OF ORGANOCHLORINE AND ORGANOPHOSPHATE INSECTICIDES IN VIVO
TOXICOLOGICAL INTERACTION OF ORGANOCHLORINE AND ORGANOPHOSPHATE INSECTICIDES IN VIVO
| dc.contributor.author | KIFASI, I. I. | |
| dc.date.accessioned | 2014-02-10T09:23:13Z | |
| dc.date.available | 2014-02-10T09:23:13Z | |
| dc.date.issued | 1989-01 | |
| dc.description | A THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL, AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF THE DEGREE OF MASTER OF SCIENCE IN PHARMACOLOGY DEPARTMENT OF PHARMACOLOGY AND CLINICAL PHARMACY FACULTY OF PHARMACEUTICAL SCIENCES AHMADU BELLO UNIVERSITY, ZARIA, NIGERIA JANUARY, 1989. | en_US |
| dc.description.abstract | Acute symptoms of toxicity and median lethal dose (LDso) values by the intraperitoneal route over 24 hours for commercial formulations of dimethoate (Rogor® and Perfekthion®), aldrin and lindane were determined in mice. The difference found in LDso values for Rogor® (272. 1mg/kg) and Perfekthion® (165mg/kg) formulations of dimethoate showed that differences in formulations could alter the toxicity of technical grade compounds. Aldrin (LDso, 40mg/kg) was found to be more toxic than lindane (LDso, 249 0mg/kg). Interactions between aldrin, and lindane individually with dimethoate were investigated in vivo in mice. Decreased dimethoate survival time was observed in mice pretreated for four days with a single dose of 16mg/kg aldrin. The data (Table IX) on the effect of aldrin on mice weight and feed intake appear to suggest that this decrease (in survival time) could be due to anorexic effects on the mice which interferred with their feeding habits, rather than induction of hepatic microsomal enzymes produced by aldrin. Two days lindane pretreatiuenc of mice with a single dose of 98mg/kg, increased dimethoate survival time. By viii reducing the pentobarbitone sleeping time, exposure to lindane appears to offer potection to dimethoate toxicity by a mechanism in the animals that appears to involve an induction of the hepatic microsomal enzymes; since the same dose of lindane shortened the pentobarbitone sleeping time in mice. Subchronic daily intraperitoneal exposure to 25, 50 and lOOmg/kg of dimethoate over thirty days produced histologic lesions in the lungs, livar, and kidneys of some of the animals. These most probably were due to secondary effects of the pesticides on the tissues of the animals. It was concluded that exposure to moderate doses of organochlorires especially those with a high inductive effect on the liver enzyme may decrease the mammalian toxicity of some or ganophosphates. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/759 | |
| dc.language.iso | en | en_US |
| dc.subject | TOXICOLOGICAL, | en_US |
| dc.subject | INTERACTION, | en_US |
| dc.subject | ORGANOCHLORINE, | en_US |
| dc.subject | INSECTICIDES, | en_US |
| dc.subject | VIVO. | en_US |
| dc.title | TOXICOLOGICAL INTERACTION OF ORGANOCHLORINE AND ORGANOPHOSPHATE INSECTICIDES IN VIVO | en_US |
| dc.type | Thesis | en_US |