NEUROBEHAVIOURAL EFFECTS OF HYDRO-METHANOL LEAF EXTRACT OF Bryophyllum pinnatum IN MICE.
NEUROBEHAVIOURAL EFFECTS OF HYDRO-METHANOL LEAF EXTRACT OF Bryophyllum pinnatum IN MICE.
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Date
2012-09
Authors
JOSEPH, MOMOH,
IBRAHIM.
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Abstract
There are thousands of plants that are used traditionally in Africa for the management of
anxiety disorders, convulsion, motor disturbances and sleep disorders. However, only a few
have received scientific scrutiny. This study was carried out to evaluate the effect of the
hydro-methanol leaf extract of Bryophyllum pinnatum (family: Crassulaceae) in some
neurobehaviours in mice weighing between 25-30g at doses of 25, 50 and 100mg/kg. The
parameters evaluated were the hole board test for explorative activity, beam-walking assay
for motor coordination deficit, diazepam-induced sleeping time and Pentylenetetrazole
(PTZ)-induced convulsion. The results revealed that the extract showed a statistical
significant (p<0.05) increase in the number of foot slips and beam latency at 25 and 50mg/kg.
It also showed a decrease in head dips but was not significant. It also revealed a statistical
significant (p<0.05) decrease in the onset of sleep and a statistical significant (p<0.05)
prolongation of sleep time in a dose dependent manner. The extract also showed a biphasic
activity by delaying the onset of convulsion and increasing protection at the doses of 25 and
100mg/kg in mice. The LD50 of the extract was calculated to be 400mg/kg. These results
showed that the extract possesses some central nervous system (CNS) depressant activity
which may be due to the effect or activity of one or more of the phytochemicals present in the
plant.
Description
A THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL,
AHMADU BELLO UNIVERSITY, ZARIA
IN PARTIAL FULFILMENT FOR THE AWARD OF MASTER OF SCIENCE
DEGREE IN HUMAN PHYSIOLOGY.
Keywords
NEUROBEHAVIOURAL,, EFFECTS,, HYDRO-METHANOL,, LEAF EXTRACT,, Bryophyllum,, pinnatum,, MICE.