THE ROLE OF KUPFFER CELL SURFACE LECTIN IN ERYTHROPHAGOCYTOSIS IN BOVINE Trypanosoma vivax INFECTION

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dc.contributor.authorIBRAHIM,
dc.contributor.authorNajume Doguwar Giginya
dc.date.accessioned2014-02-17T10:31:45Z
dc.date.available2014-02-17T10:31:45Z
dc.date.issued1992-08
dc.descriptionA Thesis submitted to the Postgraduate SchooL, Ahmadu BeLLo University, in Partial fulfillment of the requirements for the degree of Doctor of Philosophy (PhD Veterinary Pathology), Department of Pathology and Microbiology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria - Nigeria. August, 1997en_US
dc.description.abstractDesialylated erythrocytes from experimental Trypanosoma vivax infected goats and cattle were interacted with their respective homologous isolated liver kupffer cells in the presence of bovine calf serum, with and without lactose. The highest percentage of desialylated erythrocytes bound to Kupffer cells in conjunction with erythrophagocytosis was between 12 and 19% and 13 and 14% for the infected goats and cattle respectively. But, summing the latter percent values with regards to Kupffer cells bound to desialylated erythrocytes without erythrophagocytosis, and the existence of erythrophagocytosis without binding of red cells, much higher values of 71% and 62% were obtained in the T. vivax infected goats and cattle, respectively, without trace of lactose. Interactions of the desialylated erythrocytes from T. vivax infected goats in the presence of lactose, or T. vivax infected cattle intravenously infused with 0.5 g per kg body weight lactose, both in the presence of bovine calf serum, showed remarkable inhibition of both binding and erythrophagocytosis. Low values of 2 % and 0-1 % were obtained in goats and cattle, respctively. The inhibitory effect was accomplished through competitive binding of the kupffer cells surface lectin by lactose. The results suggest strongly that the erythrophagocytosis in acute ruminant T.vivax anaemia is partly lectin based, and the significance of these findings were discussed in relation to the control of trypanosomiasis. In a separate experiment, 2 out of 4 T. vivax infected, and 2 out of another 4 T. vivax infected-lactose infused Sokoto Gudali calves, including one out of 4 control calves were sacrificed for pathological examinations. Except for the 4 control, the remaining 8 calves were experimentally infected using 11 x 106 T. vivax trypanosomes, intravenously, as a source of neuraminidase. At the peak of parasitaemia, lactose was intravenously infused at the rate of 0.5 g kg-11 body weight into 4 of the infected calves, to inhibit the binding of desialylated erythrocytes to kupffer cellsen_US
dc.identifier.urihttp://hdl.handle.net/123456789/1710
dc.language.isoenen_US
dc.subjectKUPFFER CELL SURFACE LECTIN,en_US
dc.subjectERYTHROPHAGOCYTOSISen_US
dc.subjectBOVINEen_US
dc.subjectTrypanosoma vivax INFECTION.en_US
dc.titleTHE ROLE OF KUPFFER CELL SURFACE LECTIN IN ERYTHROPHAGOCYTOSIS IN BOVINE Trypanosoma vivax INFECTIONen_US
dc.typeThesisen_US
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