EVALUATION OF TABLETING PROPERTIES OF NATIVE AND MODIFIED STARCHES, DERIVED FROM SOLENOSTEMON ROTUNDIFOLIUS, AS TABLET BINDER AND DISINTEGRANT
EVALUATION OF TABLETING PROPERTIES OF NATIVE AND MODIFIED STARCHES, DERIVED FROM SOLENOSTEMON ROTUNDIFOLIUS, AS TABLET BINDER AND DISINTEGRANT
No Thumbnail Available
Date
2012-12
Authors
ODUOLA, ADEMOLA RASAQ
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The aim of this research was to study the tableting properties of Solenostemon
rotundifolius starch (SRS) and modified forms for use as pharmaceutical excipient by wet
granulation method of tablet production in paracetamol formulation.
The physicochemical properties of native and modified starches were investigated
and compared with Maize starch B.P. (MZS). Properties of granules and tablets formulated
with various experimental starches and gelatin (GLT) tested as binders and disintegrants at
varying concentrations of 2.5-12.5%w/w were also investigated. In order to characterize the
mode of deformation of the experimental starches the compaction studies were carried out
using Heckel plots and the tensile strength evaluated.
The dry and wet weights of starch extracted by standard method of extraction were
9.02%w/w and 18.37%w/w respectively. Pregelatinisation produced 96.23%w/w with
water (PGSW) and 57.45%w/w when precipitated with ethanol (PGSA). The pregelatinised
starches exhibited better flow properties and swelling capacity than MZS and SRS.
Granule properties such as angle of repose, Hausner’s ratio and Carr’s index
revealed that increase in concentration of materials tested as binder and disintegrant led to
improvement in flow characteristics. Tablet properties which included friability, crushing
strength and disintegration time showed that an increase in binder concentration in the
tablet led to a decrease in friability and an increase in crushing strength and disintegration
time while increase in disintegrant concentration produced the opposite effect.
The drug release for all the batches both as binder and disintegrant were below
50%. 500 mg compacts of experimental starches made using a hydraulic press at various
tableting pressures (56.6-169.9MNm-2) and investigated for deformation characteristics and
tensile strength had the ranking order for mean yield pressure, PY as
PGSA>MZS>GLT>SRS>PGSW; total plastic deformation, DA, as
SRS<GLT<PGSW<MZS<PGSA showing that SRS and PGSW deforms plastically with
fast onset of deformation while PGSA has tendency to show fragmentation before plastic
deformation. The tensile strength result showed that SRS and the modified starches
produced harder and more compact tablets compared with Maize starch B.P.
The results obtained shows that in paracetamol tablet prepared by wet granulation
method, pregelatinising SRS makes it a suitable binder and a poor disintegrant with high
bond strength. Thus, SRS, PGSW and PGSA could be useful in formulation of tablets with
desired mechanical properties.
Description
A THESIS SUBMITTED TO THE DEPARTMENT OF
PHARMACEUTICS AND PHARMACEUTICAL MICROBIOLOGY,
AHMADU BELLO UNIVERSITY, ZARIA, NIGERIA
IN PARTIAL FULFILLMENT FOR THE AWARD OF MASTERS OF
SCIENCE IN PHARMACEUTICS
DEPARTMENT OF PHARMACEUTICS AND PHARMACEUTICAL
MICROBIOLOGY, FACULTY OF PHARMACEUTICAL SCIENCES,
AHMADU BELLO UNIVERSITY, ZARIA
DECEMBER, 2012
Keywords
EVALUATION,, TABLETING PROPERTIES,, NATIVE,, MODIFIED STARCHES,, SOLENOSTEMON,, ROTUNDIFOLIUS,, TABLET BINDER, DISINTEGRANT.