EVALUATION OF TABLETING PROPERTIES OF NATIVE AND MODIFIED STARCHES, DERIVED FROM SOLENOSTEMON ROTUNDIFOLIUS, AS TABLET BINDER AND DISINTEGRANT

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dc.contributor.authorODUOLA, ADEMOLA RASAQ
dc.date.accessioned2014-02-25T13:05:44Z
dc.date.available2014-02-25T13:05:44Z
dc.date.issued2012-12
dc.descriptionA THESIS SUBMITTED TO THE DEPARTMENT OF PHARMACEUTICS AND PHARMACEUTICAL MICROBIOLOGY, AHMADU BELLO UNIVERSITY, ZARIA, NIGERIA IN PARTIAL FULFILLMENT FOR THE AWARD OF MASTERS OF SCIENCE IN PHARMACEUTICS DEPARTMENT OF PHARMACEUTICS AND PHARMACEUTICAL MICROBIOLOGY, FACULTY OF PHARMACEUTICAL SCIENCES, AHMADU BELLO UNIVERSITY, ZARIA DECEMBER, 2012en_US
dc.description.abstractThe aim of this research was to study the tableting properties of Solenostemon rotundifolius starch (SRS) and modified forms for use as pharmaceutical excipient by wet granulation method of tablet production in paracetamol formulation. The physicochemical properties of native and modified starches were investigated and compared with Maize starch B.P. (MZS). Properties of granules and tablets formulated with various experimental starches and gelatin (GLT) tested as binders and disintegrants at varying concentrations of 2.5-12.5%w/w were also investigated. In order to characterize the mode of deformation of the experimental starches the compaction studies were carried out using Heckel plots and the tensile strength evaluated. The dry and wet weights of starch extracted by standard method of extraction were 9.02%w/w and 18.37%w/w respectively. Pregelatinisation produced 96.23%w/w with water (PGSW) and 57.45%w/w when precipitated with ethanol (PGSA). The pregelatinised starches exhibited better flow properties and swelling capacity than MZS and SRS. Granule properties such as angle of repose, Hausner’s ratio and Carr’s index revealed that increase in concentration of materials tested as binder and disintegrant led to improvement in flow characteristics. Tablet properties which included friability, crushing strength and disintegration time showed that an increase in binder concentration in the tablet led to a decrease in friability and an increase in crushing strength and disintegration time while increase in disintegrant concentration produced the opposite effect. The drug release for all the batches both as binder and disintegrant were below 50%. 500 mg compacts of experimental starches made using a hydraulic press at various tableting pressures (56.6-169.9MNm-2) and investigated for deformation characteristics and tensile strength had the ranking order for mean yield pressure, PY as PGSA>MZS>GLT>SRS>PGSW; total plastic deformation, DA, as SRS<GLT<PGSW<MZS<PGSA showing that SRS and PGSW deforms plastically with fast onset of deformation while PGSA has tendency to show fragmentation before plastic deformation. The tensile strength result showed that SRS and the modified starches produced harder and more compact tablets compared with Maize starch B.P. The results obtained shows that in paracetamol tablet prepared by wet granulation method, pregelatinising SRS makes it a suitable binder and a poor disintegrant with high bond strength. Thus, SRS, PGSW and PGSA could be useful in formulation of tablets with desired mechanical properties.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/2648
dc.language.isoenen_US
dc.subjectEVALUATION,en_US
dc.subjectTABLETING PROPERTIES,en_US
dc.subjectNATIVE,en_US
dc.subjectMODIFIED STARCHES,en_US
dc.subjectSOLENOSTEMON,en_US
dc.subjectROTUNDIFOLIUS,en_US
dc.subjectTABLET BINDERen_US
dc.subjectDISINTEGRANT.en_US
dc.titleEVALUATION OF TABLETING PROPERTIES OF NATIVE AND MODIFIED STARCHES, DERIVED FROM SOLENOSTEMON ROTUNDIFOLIUS, AS TABLET BINDER AND DISINTEGRANTen_US
dc.typeThesisen_US
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