PHYTOCHEMICAL AND ANTIMICROBIAL STUDIES OF MORINDA LUCIDA (BENTH) LEAF AND UAPACA TOGOENSIS (PAX) STEM BARK EXTRACTS

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dc.contributor.authorOMACHI, ANDREW ATAI
dc.date.accessioned2016-04-26T09:00:11Z
dc.date.available2016-04-26T09:00:11Z
dc.date.issued2015-03
dc.descriptionDepartment of Chemistry, Ahmadu Bello University Zaria, Zaria 810282, Nigeriaen_US
dc.description.abstractA new flavonoid, 2-(3,5-dihydroxy-4-methoxy-phenyl)-3,5-dihydroxy-8,8-dimethyl- 2,3-dihydro-8H-pyrano[3,2]chromen-4-one, together with previously reported epica- techin was isolated from the ethyl acetate soluble fraction of the methanol extract of the stem bark of Commiphora pedunculata. The structures of these compounds were elucidated based on extensive analysis of their spectral data, including 1 and 2D NMR. The compounds were active against 9 out of 12 tested microorganisms including a resistant strain; vancomycin-resistant entrococci (VRE), Escherichia coli. Staphylo-coccus aureus and Candida albicans. The zones of inhibition ranged between 22 and 34 mm against the microorganisms. The minimum inhibitory concentration was as low as 6.25 µxg/mL againstShigella dysentriae. Bacillus cereus and S. aureus while the minimum bactericidal concentration was as low as 50 µxg/mL against Pseudomonas aeruginosa, VRE and C. albicans. This is the first report of the isolation of the compound.en_US
dc.identifier.urihttps://kubanni.abu.edu.ng/handle/123456789/7770
dc.language.isoenen_US
dc.subjectnovel,en_US
dc.subjectantimicrobial,en_US
dc.subjectflavonoid VRE,en_US
dc.subjectstem bark,en_US
dc.subjectCommiphora pedunculata,en_US
dc.subject(Kotschy & Peyr.) Engl,en_US
dc.subject2D NMR,en_US
dc.titlePHYTOCHEMICAL AND ANTIMICROBIAL STUDIES OF MORINDA LUCIDA (BENTH) LEAF AND UAPACA TOGOENSIS (PAX) STEM BARK EXTRACTSen_US
dc.typeThesisen_US
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