ISOLATION AND CHARACTERIZATION OF MEDICINAL PRINCIPLES OF Pouteria alnifolia BAKER ROBERTY (SAPOTACEAE)
ISOLATION AND CHARACTERIZATION OF MEDICINAL PRINCIPLES OF Pouteria alnifolia BAKER ROBERTY (SAPOTACEAE)
| dc.contributor.author | ANYAM, JOHN VERSHIMA | |
| dc.date.accessioned | 2014-03-06T08:09:54Z | |
| dc.date.available | 2014-03-06T08:09:54Z | |
| dc.date.issued | 2011 | |
| dc.description | A THESIS SUBMITTED TO THE SCHOOL OF POSTGRADUATE STUDIES, AHMADU BELLO UNIVERSITY, ZARIA, IN PARTIAL FULFILMENT OF THE REQUIREMENT FOR THE DEGREE OF MASTER OF SCIENCE (MSC) IN ORGANIC CHEMISTRY. DEPARTMENT OF CHEMISTRY, FACULTY OF SCIENCE, AHMADU BELLO UNIVERSITY, ZARIA. 2011 | en_US |
| dc.description.abstract | Phytochemical screening of the plant Pouteria alnifolia indicated the presence of tannins, sterols, cardiac glycosides, flavonoids but no alkaloids. Two triterpenes have been isolated from the stem bark and identified by GC-MS, and Carbon-13 NMR analyses as Betulin and Lupeol. The extracts from the stem back were found to be antifungal: effective against Aspergillus nigre, Trichophyton rubrum, and Candida albicans inhibiting their growths at minimum concentrations of 10mg/ml, 20mg/ml and 5mg/ml respectively; and completely killing Aspergillus nigre and Candida albicans at minimum fungicidal concentrations of30mg/ml, 40mg/ml and 10mg/ml, respectively. Antibacterial screening of the methanol and ethyl acetate extracts showed activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, and Candida albicans, at 0.625mg/ml, 0.625mg/ml, 1.25mg/ml, 1.25mg/ml, and 1.25mg/ml respectively for the ethyl acetate extracts but the methanol extract showed 1.25mg/ml for Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, and Candida albicans. Minimum bactericidal concentrations of the extracts against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, and Candida albicans were found to be 1.25mg/ml, 1.25mg/ml, 5mg/ml, 5mg/ml, and 5mg/ml respectively for ethyl acetate extract and a 5mg/ml for the methanol extract in turn, with Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, and Candida albicans.The methanol extract was found to be active against Trypanosoma brucei brucei, in an in vitro test, killing all the parasites at a minimum concentration of 5mg/ml in 10 minutes as opposed to the standard drug Diminaveto® 100mg/ml in 3 minutes. The above findings mark Pouteria alnifolia as an important medicinal plant | en_US |
| dc.identifier.uri | https://kubanni.abu.edu.ng/handle/123456789/3308 | |
| dc.language.iso | en | en_US |
| dc.subject | ISOLATION, | en_US |
| dc.subject | CHARACTERIZATION, | en_US |
| dc.subject | MEDICINAL, | en_US |
| dc.subject | PRINCIPLES, | en_US |
| dc.subject | Pouteria alnifolia, | en_US |
| dc.subject | BAKER ROBERTY | en_US |
| dc.subject | SAPOTACEAE | en_US |
| dc.title | ISOLATION AND CHARACTERIZATION OF MEDICINAL PRINCIPLES OF Pouteria alnifolia BAKER ROBERTY (SAPOTACEAE) | en_US |
| dc.type | Thesis | en_US |
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