CHARACTERIZATION OF ANTIBIOTIC RESISTANCE GENES FROM SALMONELLA ASSOCIATED WITH INVASIVE SALMONELLOSIS IN SELECTED HOSPITALS IN KATSINA STATE, NIGERIA

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dc.contributor.authorISAH, Isah
dc.date.accessioned2017-12-11T09:35:21Z
dc.date.available2017-12-11T09:35:21Z
dc.date.issued2016-12
dc.descriptionA DISSERTATION SUBMITTED TO THE SCHOOL OF POSTGRADUATE STUDIES, AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF MASTER OF SCENCE DEGREE IN MICROBIOLOGY DEPARTMENT OF MICROBIOLOGY, FACULTY OF SCIENCE AHMADU BELLO UNIVERSITY, ZARIA NIGERIAen_US
dc.description.abstractThe present research work was carried out to characterize the antibiotic resistance of Salmonella serovars associated with invasive salmonellosis in selected hospitals in Katsina State. A total of 300 blood samples was collected from the patients at three General hospitals [General hospital Katsina, Daura and Baure] and were processed according to standard microbiological technique for isolation and identification ofSalmonella typhiand Salmonella paratyphiA from 14 samples,the result of serotyping (slide agglutination) of the isolates indicates that nine (9) serovars belonged to D group while five (5) of the serovars belonged to A group. The antibiotic susceptibility test that was carried out among the isolates against seven (7) antibiotics showed 88.9% resistance to ampicillin by Salmonella entericaserovarTyphi only, 100% resistance to penicillin G by both serovars and 100% sensitivity to ampicillin (by Salmonella paratyphi A only), Chloramphenicol, Gentamicin, Cephalex, Ofloxacin and Trimethoprim – sulfomethoxazole. The PCR analysis detected the presenceof blaTEM-1gene in eight (8) serovars of Salmonella entericaserovarTyphi only.This study confirmed the presence of Salmonella entericaserovarTyphi and Salmonella entericaserovarParatyphi A as the cause of invasive salmonellosis in the study, their susceptibility and resistance to antimicrobial agents. The study emphasized the use of antibiotics likeofloxacin, cephalex chloramphenicol and septrin for treating enteric fever.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/9643
dc.language.isoenen_US
dc.subjectCHARACTERIZATION,en_US
dc.subjectSALMONELLA ASSOCIATED WITH INVASIVE SALMONELLOSISen_US
dc.subjectANTIBIOTIC RESISTANCE GENES,
dc.subjectSALMONELLA,
dc.subjectNVASIVE SALMONELLOSIS,
dc.subjectHOSPITALS IN KATSINA STATE,
dc.subjectNIGERIA
dc.titleCHARACTERIZATION OF ANTIBIOTIC RESISTANCE GENES FROM SALMONELLA ASSOCIATED WITH INVASIVE SALMONELLOSIS IN SELECTED HOSPITALS IN KATSINA STATE, NIGERIAen_US
dc.typeThesisen_US
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