EVALUATION OF THE AFFINITY OF THE COMPONENTS OF BLOOD AND FUR OF ALBINO RAT FOR BIOACCUMULATION OF CHROMIUM (VI) ION FOLLOWING MILD EXPOSURE
EVALUATION OF THE AFFINITY OF THE COMPONENTS OF BLOOD AND FUR OF ALBINO RAT FOR BIOACCUMULATION OF CHROMIUM (VI) ION FOLLOWING MILD EXPOSURE
No Thumbnail Available
Date
2015-10
Authors
Omoniyi, K. I.
Ekwumemgbo, P. A.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The study investigates the affinity of chromium (VI) ion for the components of blood and fur
of female albino rats after spaced dosing with 5 mL and 1 mL of 1.0 μg/mL K2Cr2O7 solution
intraperitoneally in May, 2012; for application in forensic analyses following industrial and
environmental exposures. The level of total-Cr ions was determined in the serum, red blood
cell, plasma and fur of the experimental female albino rats after dosing with 5 mL of 1.0
μg/mL K2Cr2O7 solution intraperitoneally in day 1, and 1 mL of the same solution on day 8 of
the experiment, using atomic absorption spectrophotometry. After two weeks of K2Cr2O7
administration, 12.127 ± 0.726 μg/mL, 2.956 ± 0.003, 2.210 ± 0.002 and 4.090 ± 0.0078
μg/mL were the mean levels of ions in the serum, red blood cell (RBC), plasma and fur
respectively. There was no significant weight increase in the experimental group compared
to the control group during the dosing period; however, the experimental group showed
passiveness, consumed less feed, but had more water intake compared to the control group.
The ranking for the mean level of total-Cr ions in the experimental rat followed the ranking,
serum > fur > red blood cell (RBC) > plasma; while the control had the ranking serum > fur
> plasma > RBC. There was high statistical increase in the ions in the serum of the
experimental rat compared to the control; likewise the level in the experimental fur was
highly elevated compared to the control (P < 0.05). The total-Cr ions in the fur and serum
were doubled due to the administration of K2Cr2O7 solution to the rats. The findings of the
study signaled that the fur and serum can equally serve as specimen for detection of mild
exposure to Cr (VI) during forensic investigation.
Description
postprint journal article
Keywords
EVALUATION,, albino rat;, blood component;, chromium (VI) ion;, forensic;, mild exposure