PREVALENCE OF HUMAN PAPILLOMAVIRUS IN ASSOCIATION WITH CD4+ COUNT AMONG HIV POSIIVE WOMEN ATTENDING BARAU DIKKO TEACHING HOSPITAL IN KADUNA, NIGERIA

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dc.contributor.authorUMAR, Fatima Jummai
dc.date.accessioned2017-12-21T12:50:34Z
dc.date.available2017-12-21T12:50:34Z
dc.date.issued2016-06
dc.descriptionA DISSERTATION SUBMITTED TO THE SCHOOL OF POSTGRADUATE STUDIES, AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILMENT OF THE REQUIREMENT FOR THE AWARD OF MASTERS DEGREE IN MICROBIOLOGY DEPERTMENT OF MICROBIOLOGY, FACULTY OF LIFE SCIENCES, AHMADUBELLO UNIVERSITY, ZARIA, NIGERIAen_US
dc.description.abstractHuman papillomavirus (HPV) is the cause of 90-95% of squamous cell cancers. Persistent infection with high risk HPV can lead to development of cervical cancer. This study was conducted to determine the prevalence of HPV immunoglobulin G (IgG) antibodies and its association with CD4+ count among HIV positive women attending Barau Dikko Teaching Hospital in Kaduna, Nigeria. The study was descriptive, cross-sectional and experimental combining the use of structured questionnaire and as well as analysis of whole blood for CD4+ count and serum for IgG antibodies to HPV using Beckton Dickinson FACS Count and ELISA accordingly.The prevalence of IgG antibody to HPV was found to be 21.9% (59/270) in 270 HIV positive women who came for their CD4+ count in Barau Dikko Teaching Hospital in Kaduna Metropolis, Kaduna State, Nigeria. Women in the age group 20-29 had the highest prevalence of 38.9% (21/54). In this study, IgG antibodies to HPV was predominant in the younger than the older women who had their first sexual intercourse in the age bracket 10-19 years and had the highest prevalence 23.0% (31/135) of HPV. The result varied with the socio-demographic factors but was only significantly associated with educational status, age, religion and women having children (P< 0.05). The results also insignificantly varied with the reproductive and sexual behavior of the women. The prevalence of HPV among the HIV positive women with CD4+ count greater than 200cells/mm3 was higher 22.0% (53/241) compared to 21.4% (6/28) obtained among those with CD4+ count less than 200cells/mm3.Further studies on the prevalence of high risk serotypes of HPV among HIV positive and negative women as well as HPV related malignancies among women is recommended.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/9869
dc.language.isoenen_US
dc.subjectPREVALENCE,en_US
dc.subjectHUMAN PAPILLOMAVIRUS,en_US
dc.subjectASSOCIATION,en_US
dc.subjectCD4+ COUNT,en_US
dc.subjectHIV POSIIVE WOMEN,en_US
dc.subjectBARAU DIKKO TEACHING HOSPITAL,en_US
dc.subjectKADUNA,en_US
dc.subjectNIGERIAen_US
dc.titlePREVALENCE OF HUMAN PAPILLOMAVIRUS IN ASSOCIATION WITH CD4+ COUNT AMONG HIV POSIIVE WOMEN ATTENDING BARAU DIKKO TEACHING HOSPITAL IN KADUNA, NIGERIAen_US
dc.typeThesisen_US
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