ASSESSMENT OF NORMAL TISSUE COMPLICATION PROBABILITY FOR PATIENTS UNDERGOING EXTERNAL BEAM RADIOTHERAPY OF CANCER OF THE CERVIX

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dc.contributor.authorONUH, ECHECHE
dc.date.accessioned2015-02-25T07:41:35Z
dc.date.available2015-02-25T07:41:35Z
dc.date.issued2014-08
dc.descriptionA thesis submitted to the school of postgraduate studies, Ahmadu Bello University, Zaria. In Partial fulfillment of the requirements for the Award of Masters Degree of science in radiation biophysics, Department of Physics, Faculty of Science Ahmadu Bello University, Zaria Nigeria. DEPARTMENT OF PHYSICS, FACULTY OF SCIENCES, AHMADU BELLO UNIVERSITY, ZARIA. NIGERIA AUGUST, 2014en_US
dc.description.abstractThe effect of cervical cancer treatment on women was re-examined in the northern Nigeria with a view to observe the resulting effect of the available diagnosis and treatment procedures. Although, modern radiation therapy techniques which includes External Beam Radiotherapy (EBRT), have the ability to conform the dose distribution of ionizing radiation tightly around the volume to be treated, unwanted irradiation to surrounding organs remains a problem. Three basic methods were followed during the radiotherapy planning of these patients which included the pre-planning stage, planning radiotherapy treatment stage and treatment delivery. Various tests were carried out on these patients which helped to confirm the diagnosis after which they were treated using the linear accelerator, computed tomography simulator and the treatment planning system. The probability of a side effect arising in the normal tissue of a patient after radiation therapy was modelled by sigmoid mathematical functions known as normal tissue complication probability (N.T.C.P) models. Hence, to compute N.T.C.P in this research work, the linear equation used in the work developed by Emami et al (1991) was used. This equation has three tissue specific parameters, aG, k & N0, and three variables (NTCP, dose and volume of the organ). The equation has been applied to compute the above said three parameters of the NTCP model using the doses of normal tissues / organs around the cervix extracted from cervical cancer patients under study at the Usman Danfodio University Teaching Hospital. The graphs obtained from this work show that all the organs (bladder, rectum, gastro-intestine, left femur, right femur and skin) are dose and volume dependent and also exhibit a threshold dose for the whole volume (plotted data) above which a complication arises. The threshold doses for bladder, rectum, gastro-intestine, left femur, right femur and skin are at 5Gy, 6Gy, 21Gy, 5Gy, 2Gy and 7Gy respectively. Fitting equations were also obtained for each curve and a line of best fit was obtained using the method of least square fit. A C++ program code was written to help in the plotting computation and the Gnuplot plotting software was used for both the plots and fitting. This retrospective study was carried out on a total number of 50 non-pregnant cervical cancer patients.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/6082
dc.language.isoenen_US
dc.subjectNORMAL TISSUE,en_US
dc.subjectCOMPLICATION,en_US
dc.subjectPROBABILITY,en_US
dc.subjectBEAM RADIOTHERAPY,en_US
dc.subjectCANCERen_US
dc.subjectCERVIXen_US
dc.titleASSESSMENT OF NORMAL TISSUE COMPLICATION PROBABILITY FOR PATIENTS UNDERGOING EXTERNAL BEAM RADIOTHERAPY OF CANCER OF THE CERVIXen_US
dc.typeThesisen_US
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