EFFECTS OF ANTIMALARIAL DRUGS ON OESTROUS CYCLE AND UTERINE CONTRACTILITY IN RATS

Simple item page
dc.contributor.authorUSMAN, Maryam wawata
dc.date.accessioned2021-08-16T08:56:15Z
dc.date.available2021-08-16T08:56:15Z
dc.date.issued2014-11
dc.descriptionTHESIS SUBMITTED TO THE SCHOOL OF POSTGRADUATE STUDIES AHMADU BELLO UNIVERSITY IN PARTIAL FULFILLMENT OF THE REQUIREMENT FOR THE AWARD OF A MASTER DEGREE IN PHARMACOLOGY DEPARTMENT OF PHARMACOLOGY AND THERAPEUTICS, FACULTY OF PHARMACEUTICAL SCIENCES, AHMADU BELLO UNIVERSITY, ZARIA, NIGERIAen_US
dc.description.abstractMalaria is increasingly a health burden globally with children under the age of 5 and pregnant women being the most vulnerable. Several antimalarials are available in the market today however; the safety data in pregnancy is inadequate especially the first trimester of pregnancy. The study was carried out in both pregnant and non-pregnant wistar rats to evaluate the effect of these antimalarial drugs on the oestrous cycle as well as on the uterine smooth muscle contractility. All the antimalarial drugs in this study (AT 3.2 mg/kg loading dose and 1.6 mg/kg maintenance dose for 7 days; CQ 2.5 mg/kg every 4 hours; QN 20 mg/kg loading dose and 10 mg/kg maintenance dose 8 hourly for 7 days and SP 25 mg/1.25 mg/kg once); showed a desynchronization of the normal oestrous cycle. Proestrus phase was increased by all the antimalarial drugs except for AT, oestrus phase was decreased by all but significantly by QN and metoestrus was increased by all except SP which decreased it significantly while the dioestrus phase, a decrease was observed. On isolated uterine smooth muscle of pregnant rat, artemether (AT, 16 μg/ml – 1280 μg/ml) Chloroquine (CQ, 4 mg/ml – 32 mg/ml), quinine (QN 100 ng/ml – 800 ng/ml) and sulphadoxine /pyrimethamine (SP, 100 μg/ml – 400 μg/ml ), had no agonist effect on the uterus but AT (16 μg/ml – 1280 μg/ml), CQ (16 mg/ml) and SP (100 μg/ml) produced a reduction in oxytocin induced contraction of the pregnant uterus. In conclusion, this study showed that these antimalarial drugs caused a desynchronization of the normal oestrous cycle suggesting a possible effect on the menstrual cycle in women of child bearing age while the reduction in the oxytocin induced contraction could translate to ill effect especially in late pregnancy and during labour.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/12495
dc.language.isoenen_US
dc.subjectEFFECTS OF ANTIMALARIAL DRUGS,en_US
dc.subjectOESTROUS CYCLE,en_US
dc.subjectUTERINE CONTRACTILITY,en_US
dc.subjectRATS,en_US
dc.titleEFFECTS OF ANTIMALARIAL DRUGS ON OESTROUS CYCLE AND UTERINE CONTRACTILITY IN RATSen_US
dc.typeThesisen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
EFFECTS OF ANTIMALARIAL DRUGS ON OESTROUS CYCLE AND UTERINE CONTRACTILITY IN RATS.pdf
Size:
1.96 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.62 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
PHARMACEUTICAL SCIENCES