CHEMICAL ANALYSES OF THE BARKS OF ANOGEISSUS LEOCARPUS AND F1CUS 1TTE0PHYLLA

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dc.contributor.authorADIGUN, JOHN OYEYIOLA
dc.date.accessioned2014-02-11T11:11:01Z
dc.date.available2014-02-11T11:11:01Z
dc.date.issued1998-11
dc.descriptionA THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL, AHMADU BELLO UNIVERSITY, ZARIA-NIGERIA IN PARTIAL FULFILMENT OF THE REQUIREMENT FOR THE DEGREE OF DOCTOR OF PHILOSOPHY IN ANALYTICAL CHEMISTRY DEPARTMENT OF CHEMISTRY FACULTY OF SCIENCE, AHMADU BELLO UNIVERSITY, ZARIA-NIGERIAen_US
dc.description.abstractCompounds were extracted from the bark of the plants Anogeissus let/carpus and Fiats ittcophylla using the extracting solvents petroleum spirit, n-hexane. ethyl acetate. chloroform, ethanol, methanol and water. The extracts which are mainly solids were purified by column chromatography and / recrystallisation F'etrolcum spirit and chloroform extracts of Anogeissus leocarpus contain mainly hexadecanoic, oleic and linoleic acid and some carboxylic acid esters. The polyhdroxy compounds mannitol, glycerol, sucrose, a- and B-D-glucose together with 3,4,3'-tri-()- methylflavellagic acid and the glycosides ethyl fructose and 3.4.3-tri-()-methylflvellagic acid-4'-()-glucosidc were identified from the methanol and ethanol extracts. The aqueous extract contains alpha- and beta-D-glucose, mannitol, levulinic acid and ethyl fructose All these identification were made from 'H. 13C and 1H-1H-COSY NMR spectra, IV, IR, GC-MS and 3-part TLC with authentic samples Cytotoxicity experiments on the crude methanol, ethanol and aqueous extracts on Anemia salina show that they have an LC50 of 563 ± 9 |ig/cm"\ 163 ±10ug/cm3 and 163 ± 10 jig/cm' respectively. These extracts and the isolated 3,4,3',-tri-O-mcthyyivellagic acid-4'- ()-glucoside also possess growth inhibitory effects on Staphylococcus aureus, Estheriaa coli, Pseudomonas aeruginosa and Candida albicans at various concentrations. The bark of Fiats illeophylia was extracted with organic solvents and water as was Anogeissus leocarpus. 'H, 13C and 'H-'H-COSY NMR, UV, IR, GC-MS and 3-part TLC with authentic samples indicate that the plant contains hexadecanoic, octadecanoic nonadecanoic, decanoic quinic and lactic acids, alpa- and beta-D-glucosc. mannitol, catechol, and 4-(2'-dimethylaminoethylphenol) i.e hordeninc (which is now being reported for the first time as a constituent of the plant) Pharmacologocal experiments on the effects of ethanol and aqueous extracts on the smooth muscle indicates that they possess dose dependent contraction effects. Hordenine possesses both contraction and relaxation effects respectively at low concentration and high concentrations and is probably the active principle in the drugen_US
dc.identifier.urihttp://hdl.handle.net/123456789/1176
dc.language.isoenen_US
dc.subjectCHEMICAL ANALYSES,en_US
dc.subjectBARKS,en_US
dc.subjectANOGEISSUS LEOCARPUS,en_US
dc.subjectF1CUS 1TTE0PHYLLAen_US
dc.titleCHEMICAL ANALYSES OF THE BARKS OF ANOGEISSUS LEOCARPUS AND F1CUS 1TTE0PHYLLAen_US
dc.typeThesisen_US
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