THE EFFECT OF ORAL INGESTION OF FUSARIUM OXYSPORUM INOCULATED SORGHUM ON THE HISTOLOGY OF KIDNEY AND LIVER OF ADULT WISTAR RATS (RATTUS NOVEGICUS)
THE EFFECT OF ORAL INGESTION OF FUSARIUM OXYSPORUM INOCULATED SORGHUM ON THE HISTOLOGY OF KIDNEY AND LIVER OF ADULT WISTAR RATS (RATTUS NOVEGICUS)
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Date
2008-09
Authors
ANOSIKE, VICTOR IKENNA
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Abstract
Fusarium oxysporum is an important pathogen of a wide range of
crop plants. The study was conducted to investigate the effect of
feeding a blend of sorghum grains contaminated with Fusarium
oxysporum on the blood picture and the histology of the kidney and
liver of adult wistar rats. A total of thirty (30) rats of the wistar
species weighing between 150 and 180g were divided into four
experimental groups and a control group comprising six(6) rats in
each group and fed for twenty eight days(28).The diet consisted
control(group 1),25% contaminated meal(group 2),50%
contaminated(group 3),75% contaminated(group 4) and 100%
contaminated meals(group 5).
At the end of the experiment the RBC, WBC and differential
WBC counts did not show any significant differences (P 0.05).the
histological studies however showed damage to the kidney tissue
under light microscopy. They were characterized by degraded renal
tubules, necrosis of glomerular cells, and apoptotic bodies in areas
between the renal tubules infiltrated by mononuclear cells.
The liver histology showed by light microscopy, loss of hepatic
architecture, pyknotic nuclei and infiltration by mononuclear cells.
It was therefore concluded that Fusarium oxysporum has caused
marked inflammation and tubular necrosis in the rat’s kidney as
well as inflammation and parenchymal necrosis in the liver with no
significant changes in the blood picture.
Description
A THESIS SUBMITTED TO THE POSTGRADUATE
SCHOOL IN PARTIAL FULFILLMENT OF THE
REQUIREMENTS FOR THE AWARD OF THE DEREE
OF MASTER OF SCIENCE IN HUMAN ANATOMY
DEPARTMENT OF HUMAN ANATOMY
FACULTY OF MEDICINE
AHMADU BELLO UNIVERSITY
ZARIA
NIGERIA.
Keywords
ORAL,, EFFECT,, INGESTION,, FUSARIUM,, OXYSPORUM,, INOCULATED, SORGHUM,, HISTOLOGY, KIDNEY,, LIVER,, ADULT,, WISTAR, RATS,, (RATTUS NOVEGICUS)