STUDIES ON IN VIVO AND IN VITRO EFFECTS OF PRE-EXPOSURE TO LINDANE ON COUMAPHOS TOXICITY IN RATS AND ISOLATED RABBIT ILEUM

Simple item page
dc.contributor.authorRAMON-YUSUF, SULEIMAN BABATUNDE (DVM).
dc.date.accessioned2014-11-04T09:17:04Z
dc.date.available2014-11-04T09:17:04Z
dc.date.issued1993-01
dc.descriptionA THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL, AHMADU BELLO UNIVERSITY, ZARIA. IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF THE DECREE OF MASTER OF SCIENCE IN ENVIRONMENTAL TOXICOLOGY DEPARTMENT OF PHYSIOLOGY AND PHARMACOLOGY FACULTY OF VETERINARY MEDICINE AHMADU BELLO UNIVERSITY, ZARIA, NIGERIA. JANUARY, 1993en_US
dc.description.abstractInvestigations were conducted into the in vitro and in vivo effects of pre-exposure to lindane on coumaphos toxicity. In vitro Lindane was found to attenuate the response of the cholinergic receptor to coumaphos. When the calcium ion concentration of the medium was reduced by use of the calcium antagonist nifedipine, an augmentation of the effect of Lindane was observed. This effect became more profound as indicated by weaker muscular contractions in a calcium - free medium. A 10-week subchronic toxicity study in rats suggests that pre-exposure to Lindane offers some protection against coumaphos toxicity as indicated by the mildness of the histopathological lesions in groups of animals pretreated with Lindane vis-a-vis those that did not receive lindane pretreatment prior to exposure to the same dose levels of coumaphos. The intraperitoneal median lethal dose (LD50) of coumaphos in rats was found to be 139.6 mg/kg. In Lindane pre-teated and non pre-treated animals, coumaphos did not affect the organ; body weight ratio.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/5508
dc.language.isoenen_US
dc.subjectVIVO,en_US
dc.subjectVITRO EFFECTS,en_US
dc.subjectPRE-EXPOSUREen_US
dc.subjectLINDANE,en_US
dc.subjectCOUMAPHOS,en_US
dc.subjectTOXICITY,en_US
dc.subjectRATS,en_US
dc.subjectISOLATED,en_US
dc.subjectRABBIT ILEUMen_US
dc.titleSTUDIES ON IN VIVO AND IN VITRO EFFECTS OF PRE-EXPOSURE TO LINDANE ON COUMAPHOS TOXICITY IN RATS AND ISOLATED RABBIT ILEUMen_US
dc.typeThesisen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
RAMON-YUSUF, SULEIMAN BABATUNDE.pdf
Size:
8.47 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.58 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
VETERINARY MEDICINE